Antimutagenic Constituents from the Thorns of Gleditsia sinensis
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概要
- 論文の詳細を見る
Antimutagenic activity-guided fractionation of an extract prepared from the thorns of Gleditsia sinensis LAM. led to the isolation of one triterpenoid and four steroids, which were identified as D:C-friedours-7-en-3-one (1), stigmast-4-ene-3,6-dione (2), stigmastane-3,6-dione (3), stigmasterol (4), and β-sitosterol (5). Triterpenoid 1 was found for the first time in a natural source and the steroids 2-5 were first isolated from this plant. Stigmasterol was the most active antimutagen, showing 51.2% and 64.2% reduction of the induction factor against the mutagens MNNG and NQO, respectively, in the SOS chromotest. Some NMR data of the steroids 2 and 3 obtained have to be revised.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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LEE Seung
School of Advanced Materials Engineering. Chonbuk National University
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Lee Dong
Department Of Environmental Atmospheric Science Pukyong National University
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Ha J‐h
Yeungnam Univ. Taegu Kor
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Park J
Pusan National Univ. Pusan Kor
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Lee Seung
School Of Life And Health Sorabol College
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Park Jong
Department Of Pharmacology College Of Medicine Yeungnam University
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LIM Jae
Department of Chemical Engineering, Sogang University
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KOO Byung
Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University
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HAN Yeong
Department of Biology, Dongguk University
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Park Jong
College Of Pharmacy Pusan National University
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BUDESINSKY Milos
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
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KASAL Alexander
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic
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Lim Jae
College Of Pharmacy Pusan National University
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Koo Byung
Department Of Oriental Neuropsychiatry College Of Oriental Medicine Dongguk University
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Lee Seung
School Of Advanced Materials Engineering Chonbuk National University
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Han Yeong
Department Of Biology Dongguk University
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Koo B‐s
Dongguk Univ. Seoul Kor
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Lim Jae
Department Of Chemical Engineering Sogang University
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Lim J‐c
Pusan National Univ. Pusan Kor
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Lee Dong-ung
Dep. Of Biotechnology Dongguk Univ.
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Han Yeong-hwan
Department Of Biology Dongguk University
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Budesinsky Milos
Institute Of Organic Chemistry And Biochemistry Academy Of Sciences Of The Czech Republic
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Kasal Alexander
Institute Of Organic Chemistry And Biochemistry Academy Of Sciences Of The Czech Republic
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Lee Dong
Department Of Aerospace Engineering Chonbuk National University
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Lim Jae-Chul
Department of Biotechnology, Dongguk University
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