Reversal of Medetomidine-Ketamine Combination Anesthesia in Rabbits by Atipamezole
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概要
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This study was performed to determine the optimal reversal dosage of atipamezole on medetomidine-ketamine combination anesthesia. The subject rabbits were divided into five groups (n=5/group), and all were anesthetized with intravenous medetomidine (0.35 mg/kg) and ketamine (5 mg/kg). Atipamezole was administered intravenously 35 min after administration of the medetomidine-ketamine mixture, at doses of a quarter, a half, equal, or two times higher than the preceding medetomidine -ketamine dose according to experimental group. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) and rectal temperature (RT) were measured every five minutes and the mean arousal time (MAT) was also recorded. This study revealed that the optimal atipamezole dosage to achieve reversal effects is equal to or double the dose of medetomidine. At these dosages, HR and MAP significantly recovered and MAT was significantly shortened with no side effects being observed (p<0.05).
- 社団法人 日本実験動物学会の論文
著者
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KIM Min
Department of Internal Medicine, Chonnam National University Hospital
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Jeong Seong
Department Of Preventive Dentistry School Of Dentistry Kyungpook National University
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Kim Min
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Park Jae
Department of Nuclear and Energy Engineering, Jeju National University
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Kim Min-su
Departments Of Surgery College Of Veterinary Medicine Seoul National University
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Jeong Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Chungnam National University
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Park Jae
Department Of Laboratory Animal Medicine College Of Veterinary Medicine Seoul National University
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Seo Kang
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Seo Kang-moon
Department Of Animal Surgery College Of Veterinary Medicine Kangwon National University
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Seo Kang
Surgery College Of Veterinary Medicine And School Of Agricultural Biotechnology Seoul National Unive
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NAM Tchi
Department of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Seoul National U
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Jeong Seong
Department Of Veterinary Surgery College Of Veterinary Medicine Research Institute Of Veterinary Med
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Park Jae
Department Of Applied Bioscience And Biotechnology Faculty Of Life And Environmental Science
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Nam Tchi‐chou
Department Of Veterinary Surgery And Ophthalmology College Of Veterinary Medicine Seoul National Uni
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Nam T.-c.
韓国
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Jeong Seong
Department Of Chemical Engineering Sungkyunkwan University
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Kim Min
Department Of Chemical Engineering Cheju National University
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Park Jae
Department of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, South Korea
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Jeong Seong
Department of Ceramic Engineering, Yonsei University, Seoul 120-749, Korea
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Kim Min
Department of Applied Science, Korea Maritime University, Busan 606-791, Korea
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KIM Min
Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea
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