Altered Patterns of Gene Expression in Response to Chronic Atrial Fibrillation
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概要
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To obtain greater insight into atrial remodeling at the molecular level we analyzed the changes in gene expression in human atrial tissue between patients with chronic atrial fibrillation (AF) and those with normal sinus rhythm (NSR). cDNA microarray analysis was used to identify genes differentially expressed during sustained AF of more than 6 months (<i>n </i>= 9, mean age, 45 ± 12, 6 males and 3 females) as compared to those with NSR (<i>n </i>= 9, mean age, 47 ± 13, 6 males and 3 females). Western blot analysis was performed to confirm the altered gene expression and to establish the changes in protein expression. DNA gel electrophoresis to establish DNA ladder formation, which was associated with apoptosis in response to chronic AF, was performed. Microscopic findings were observed via electron microscopy. In the microarray analysis, out of 8,167 candidate genes, 66 genes showed a significant change in the expression level in the patients with chronic AF, which was in contrast to those with NSR. Among those, 31 genes were consistently down-regulated and 35 up-regulated more than 2-fold. The relative amounts of the Bcl-2 and p27 in the atrial tissue were decreased and angiotensin II type 2 (AT2) receptor and p21 were increased in the patients with chronic AF as compared to those with NSR. The atrial cardiomyocytes in chronic AF showed a prominent DNA ladder, which is a biochemical hallmark of apoptosis. The expression of Bcl-2, AT2 receptor, p21, and p27 were consistent with a significant role in the apoptosis of cardiac myocytes in the patients with chronic AF. <br>
著者
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CHO Jeong
Department of Internal Medicine, Chonnam National University Hospital
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Ahn Youngkeun
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University
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HONG Moon
Department of Cardiovascular Medicine, Chonnam National University Medical School
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Oh Seok
Department of Cardiology, Wonkwang University Hospital
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Jeong Jin-won
Departments Of Cardiovascular Medicine Wonkwang University Hospital
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Kim Nam-ho
Departments Of Cardiovascular Medicine Wonkwang University Hospital
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Choi Jong
Department Of Archaeology Kyongnam Archaeology Institute
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Park Jong
Department Mathematics Pusan National University
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Ahn Byung
Department Of Internal Medicine Hepatology Division Kangnam St. Mary's Hospital College Of Medi
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Kang Jung
Department Of Clinical Pathology Hanyang University Kuri Hospital
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Park Woo
Department Of Life Science Gwangju Institute Of Science And Technology
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Park Hyung
Department Of Electrical Engineering Korea University
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Kook Hyun
Research Institute of Medical Sciences, Chonnam National University Medical School
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Kim Yong-Sook
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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Nam Kwang
Research Institute of Medical Sciences, Chonnam National University Medical School
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Jeong Myung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Jeong Myung
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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Oh Seok
Department of Internal Medicine Wonkwang University Hospital
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Park Woo
Department of Life Science, Kwangju Institute of Science and Technology,
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Park Hyung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Ahn Youngkeun
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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AHN Byung
Department of Decontamination and Decommissioning, Korea Atomic Energy Research Institute
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Cho Jeong
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Kang Jung
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Hong Moon
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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Park Jong
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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Ahn Byung
Departments of Internal Medicine and Cardiovascular Surgery, Chonnam National University Hospital
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Choi Jong
Department of Thoracic and Cardiovascular Surgery, Wonkwang University Hospital
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Jeong Jin-Won
Department of Cardiovascular Medicine, Wonkwang University Hospital
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Jeong Jin-Won
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Kim Nam-Ho
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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