Coronary Artery Responsiveness to Ergonovine Provocation in Patients Without Vasospatic Angina A Quantitative Coronary Angiography Analysis : A Quantitative Coronary Angiography Analysis
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概要
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Even patients without vasospastic angina show vasoconstriction after intracoronary ergonovine administration. We evaluated the determinants of coronary artery responsiveness to ergonovine in such patients.In 165 patients with no provoked electrocardiographic changes or ischemic chest pain during an intracoronary ergonovine test, total cholesterol, triglycerides (TG), high density lipoprotein cholesterol (HDL), and low density lipoprotein cholesterol (LDL) were correlated with the arterial luminal diameters before and after ergonovine infusion and after nitroglycerin injection by quantitative coronary angiography analysis.The mean and maximal basal tone (ie, percent change between baseline luminal diameter and diameter after nitroglycerin) were 7.0 ± 9.9% and 27.9 ± 10.8%, respectively. The mean and maximal responsiveness to ergonovine (ie, percent change between minimal diameter during ergonovine infusion and diameter after nitroglycerin) were 30.3 ± 13.6% and 52.7 ± 16.0%, respectively. The TG level (r = 0.191, P = 0.016) and TG/HDL ratio (r = 0.182, P = 0.021) were positively correlated with the basal tone, whereas LDL level (r = 0.155, P = 0.048) and LDL/HDL ratio (r = 0.172, P = 0.030) were positively correlated with the responsiveness to ergonovine. By multivariate analysis, LDL level, LDL/HDL ratio, and smoking were independent predictors of more than 50% responsiveness to ergonovine.Serum lipid profile and smoking influence the basal tone and responsiveness to ergonovine of coronary artery in patients without vaospastic angina.
著者
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KO Jum
Department of Internal Medicine, Chonnam National University Hospital
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Oh Seok
Department of Cardiology, Wonkwang University Hospital
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Yun Kyeong
Departments of Cardiovascular Medicine, Wonkwang University Hospital
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Jeong Jin-won
Departments Of Cardiovascular Medicine Wonkwang University Hospital
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Kim Nam-ho
Departments Of Cardiovascular Medicine Wonkwang University Hospital
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Rhee Sang
Department Of Endocrinology And Metabolism Kyung Hee University School Of Medicine
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Oh Seok
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Shin Seoung-Nam
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Rhee Sang
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Yun Kyeong
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Ko Jum
Department of Cardiology, Cardiovascular Center, Clinical Trial Center, Chonnam National University Hospital
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Ko Jum
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Jeong Jin-Won
Department of Cardiovascular Medicine, Wonkwang University Hospital
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Jeong Jin-Won
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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Kim Nam-Ho
Department of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University Hospital
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