Comparative Studies on the Inhibitory Effects of Calcium Antagonists on Cytosolic Ca2+Levels Increased by High-Potassium or Glutamate in Cultured Rat Cerebellar Granule Cells.
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概要
- 論文の詳細を見る
The inhibitory effects of calcium antagonists on high-potassium or glutamate (Glu) enhanced intracellular calcium ion ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) levels were studied in cultured cerebellar granule cells. Dosages between 0.5 and 10 μM of flunarizine, nicardipine, SM6586 and SM12565 reduced the rise in [Ca<SUP>2+</SUP>]<SUB>i</SUB> induced by 50 mM KCl in a dose-dependent manner, although diltiazem, verapamil and nifedipine showed less effects on such [Ca<SUP>2+</SUP>]<SUB>i</SUB> increases. SM6586, SM12565 and flunarizine at dosages below 10 μM each reduced the magnitude of the [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase induced by 25 μM Glu, but the other examined calcium antagonists were less effective. These results suggest the dissimilar efficacy of calcium antagonists on the inhibition of [Ca<SUP>2+</SUP>]<SUB>i</SUB> levels increased by high-potassium and Glu.
- 公益社団法人 日本薬理学会の論文
著者
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Shibuya Takeshi
Department Of Agricultural Chemistry Meiji University
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Ohnishi Masatoshi
Department Of Oral & Maxillofacial Surgery Yamanashi Medical University
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Watanabe Yasuo
Department Of Agricultural Chemistry College Of Agriculture Ehime University
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Baba Tsuyoshi
Department Of Obstetrics And Gynecology Sapporo Medical University
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Ohnishi Masatoshi
Department of Pharmacology, Tokyo Medical College
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Zhang Xiang-Qian
Department of Pharmacology, Tokyo Medical College
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WATANABE Yasuo
Department of Pharmacology, Tokyo Medical College
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