Effect of a hot water extract of Agaricus blazei fruiting bodies(CJ-01) on the intracellular cytokines level in a patient with bronchitis
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概要
- 論文の詳細を見る
喘息様発作を伴う気管支炎患者において,アガリクス熱水抽出物(CJ-01)服用前後で末梢血リンパ球における細胞内サイトカインレベルをTh1系ではIL-2およびIFN-γを,またTh2系ではIL-10を測定した。CJ-01を2ヶ月服用した際には,頻回の咳,痰などの症状改善がみられ,またFlow Cytometry解析ではCJ-01服用後にIFN-γの上昇がみられた。CJ-01服用中止後3ヶ月で呼吸器症状の悪化がみられ,これと平行してIFN-γレベルの低下が認められた。しかしながらCJ-01服用再開後には,症状の改善とIFN-γレベルの上昇が認められた。患者にはさらに風邪をひきにくくなるなどの自覚もあった。これらの結果はCJ-01の免疫増強効果がIFN-γ産生増強を介して気管支炎症状を改善したことを示唆するものである。
- 和漢医薬学会の論文
- 2002-08-20
著者
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Watanabe Yasuo
Department of Cardiology, Nihon University School of Medicine
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宮本 康嗣
山口大学医学部生体防御機能学
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OKITA Kiwamu
First Department of Internal Medicine, Yamaguchi University, School of Medicine
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宮本 康嗣
分子統御系・生体防御機能学
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IIZUKA Norio
山口大学医学部生体防御機能学
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SAKAGUCHI Eiki
Department of Bioregulatoty Function, Molecular Science and Applied Medicine, Yamaguchi University S
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Okita Kiwamu
First Department Of Internal Medical Yamaguchi University School Of Medicine
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宮本 康嗣
山口大学医学部先端分子応用医科学講座生体防御機能学
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Sakaguchi Eiki
Department Of Molecular Gastroenterology And Hepatology Yamaguchi University School Of Medicine
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Sakaguchi Eiki
Department Of Bioregulatoty Function Molecular Science And Applied Medicine Yamaguchi University Sch
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Okita Kiwamu
First Department Of Internal Medicine Molecular Science And Applied Medicine Yamaguchi University Sc
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Watanabe Yasuo
Department Of Agricultural Chemistry College Of Agriculture Ehime University
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Watanabe Yasuo
Department Of Anesthesiology
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