自然発症高血圧ラットを用いたヒメマツタケ子実体熱水抽出物質 (CJ-01) の降圧効果

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Inhibitory effects of Agaricus blazei fruit hot water extract (CJ-01) on the development of hypertension in Spontaneously Hypertensive Rats (SHR) were examined. Marked hypertension occurs in 8-week old SHR and a significant increase in hypertension is shown in 10-week old SHR. Maximum hypertension occurs in 20-week old SHR. The development of hypertension seen in SHR was measured by means of the Tail Cuff method and blood/urine examinations. CJ-01 (10 g/600 ml) was extracted at 80℃ for I hr and several dosages (3 to 15 g/60 kg/day) were freely given to SHR and normotensive (WKY) rats. Animals were divided into five groups : 1) CJ-01 untreated WKY (WKY-Con) , 2) CJ-01 treated WKY from 8 th week after birth (WKY-Pre), 3) CJ-01 untreated SHR (SHR-Con), 4) CJ-01 treated SHR from 8 th week after birth (SHR-Pre) , 5) CJ-01 treated SHR from 10 th week after birth (SHR-Post). All results obtained from WKY-Con and WKY-Pre were identical, although these data were significantly different from those of SHR-Con. In the SHR-Pre group, dosages between 6 and 12 g/60 kg/day of CJ-01 significantly blocked the development of hypertension and improved the results of blood and urine examinations, particularly creatinine level, A/G ratio, total cholesterol, urine excretion and so on. Also, the SHR-POSt group exhibited a significant reduction in hypertension after 40 days of treatment, although the same dosage did not effect WKY animals. Thus CJ-01 may have prophylactic and/or therapeutic effects on hypertension and hypertensive disease.
和漢医薬学会の論文
1999-12-25

自然発症高血圧ラットを用いたヒメマツタケ子実体熱水抽出物質 (CJ-01) の降圧効果

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