DOCA-NaCl 左腎摘出ラットを用いたヒメマツタケ子実体熱水抽出物質の腎機能不全改善作用

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Renoprotective effects of Agaricus blazei fruit hot water extract (CJ-01) on the incidence and severity of renal dysfunctions in the deoxycorticosterone acetate (DOCA) -salt treated with the hemi--nephrectomized rats were investigated. CJ-01 (10 g/600 ml) was extracted 80℃ for I hr and a dose of 10 g/60 kg/day was taken, freely. Experimental animals (32 male Wistar rats) were divided into the following five groups ; I. sham-operation with 1 % NaC1, II. sham-operation with CJ-01 (for 90 days) diluted in 1 % NaCl, III. hemi-nephrectomy with DOCA (20 mg/kg s.c., one day/week for 70 days) and 1 % NaCl, IV. hemi-nephrectQmy with DOCA and CJ-01(for 90 days) diluted in 1 % NaCl, V. hemi-nephrectomy with DOCA and CJ-01 (for 49 days during the maximum hypertension was appeared) diluted in 1% NaCl. All animals were freely drinking a 1 % NaCl solution through the experimental period. After the left kidney was removed, the marked increased in volume of urine was observed in the DOCA-salt treated groups (III, IV, V). Particularly, these increases were significantly enhanced compared to I and II groups after the maximum hypertension was detected. However, in the CJ-01 treated groups (IV and V), such severe hyperurination was markedly blocked whereas the severe hypertension was not inhibited. At 90 days, the weight and size of the right-side kidney in the III group was about two folds more than those of the I and II groups, although the consecutive treatment of CJ-01 seen in the IV and V groups significantly inhibited the enlargement of right side kidney. Furthermore, the abnormal values (i.e., urine protein, cholesterol, corticosterone, etc.) detected in the urine and serum examinations of the DOCA-NaCl and hemi-nephrectomized group were significantly improved by the treatment of CJ-01. The pathological evidences also elucidated the significant uroprotecive effects of CJ -01 on the severe kidney diseases. These results indicated that CJ-01 might be a useful functional food as the prophylactic and/or treatment for severe kidney dysfunctions.
和漢医薬学会の論文
1999-04-30

DOCA-NaCl 左腎摘出ラットを用いたヒメマツタケ子実体熱水抽出物質の腎機能不全改善作用

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