培養ヒメマツタケ (CJ-01株) 子実体熱水抽出物質の自然発症糖尿病 (GK) ラットにおける膵β細胞数減少に対する改善作用

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Inhibitory effects of cultured Agaricus blazei (CJ-01) fruit hot water extract on the development of diabetes in spontaneously diabetic rats (GK rats) which are characterized as having non-obese and non-insulin dependent diabetes mellitus (NIDDM) were examined. The increase of plasma glucose level induced by a 20 % glucose solution seen in GK was significantly higher than that of normal Wistar rats. The loading of a glucose treatment was constantly performed for 12 weeks. CJ-01 (10 g/600 ml) was extracted at 80℃ for 1 hr and each dosage (3, 5, 10 g/60 kg/day) was orally given to GK rats. The GK rats were divided into five groups: 1) CJ-01 untreated and glucose loading (control), 2) CJ-01 untreated and non-glucose (non-glu) , 3) low dose of CJ-01 (3 g/60 kg/day) treated and glucose loading, 4) middle dose of CJ-01 (5 g/60 kg/day) and glucose loading (middle-CJ), 5) high dose of CJ-01 treated and glucose loading (high-CJ). The development of hyperglycemia induced by glucose was seen in the control animals. In the CJ-01 treated animals, however, the increase of plasma glucose levels were significantly attenuated. Particularly these levels of high-CJ group were much lower than those seen in control group at the 4 th week of the CJ-01 consecutive treatment. In the blood examination, all results were identical, although the significant increase of pancreatic insulin levels were detected in the high-CJ group. Histopathological study revealed evidences that CJ-01 had no effect on number of the islets among the animals. High dose of CJ-01 had increased number of pancreatic β cells at a significance level of 0.01. It had beneficial effects on foamy cell degeneration, deposition of hyaline-like substance and hypertrophy of the islets. Thus CJ-01 may have therapeutic effects on NIDDM due to the amelioration of the impaired function and he increase of pancreatic β cells.
和漢医薬学会の論文
2000-10-20

培養ヒメマツタケ (CJ-01株) 子実体熱水抽出物質の自然発症糖尿病 (GK) ラットにおける膵β細胞数減少に対する改善作用

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