Neuroprotective Effect of D-Psicose on 6-Hydroxydopamine-Induced Apoptosis in Rat Pheochromocytoma (PC12) Cells(MISCELLANEOUS)
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概要
- 論文の詳細を見る
We evaluated the neuroprotective effects of D-psicose, one of the rare sugars, on 6-hydroxy-dopamine (6-OHDA)-induced apoptosis in catecholaminergic PC12 cells, the in vitro model of Parkinson's disease (PD). Apoptotic characteristics of PC12 cells were assessed by 3-(4, 5-dimethyl-thiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay and terminal deoxynucleotidyl transferase mediated dUTP nick end-labeling (TUNEL) assay. The results showed that D-psicose at a concentration of 50mM, exerted significant protective effects against the 6-OHDA (200μM)-in-duced PC12 cell apoptosis, while other sugars had little or no protective effects. We have observed a significant increase in the level of intracellular glutathione after 24 h in 6-OHDA (200μM) treated cells, while a decrease in the level was observed at 3 h and 6 h. Also, a synergistic exposure to D-psicose and 6-OHDA for 24 h showed a significant increase in intracellular glutathione level. Therefore, these results suggest that D-psicose may play a potential role as a neuroprotective agent in the treatment of neurodegenerative diseases by inducing an up-regulation of intracellular glutathione.
- 社団法人日本生物工学会の論文
- 2005-11-25
著者
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Watanabe Yasuo
Department of Cardiology, Nihon University School of Medicine
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Watanabe Yasuo
Department Of Cardiology Nihon University School Of Medicine
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Izumori K
Rare Sugar Research Center Kagawa University
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Izumori Ken
Rare Sugar Research Center Faculty Of Agriculture Kagawa University
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Izumori Ken
Dep. Of Bioresource Sci. Fac. Of Agriculture Kagawa Univ.
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Izumori Ken
松谷化学工業 開発研究所
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Izumori Ken
Department Of Biochemistry And Food Sciences Faculty Of Agriculture Kagawa University
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TOKUDA Masaaki
Department of Physiology, Faculty of Medicine, Kagawa Medical University
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Tokuda Masaaki
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Watanabe Y
Department Of Bioresources Faculty Of Agriculture Ehime University
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Hatano Naoya
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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TAKATA Maki
Department of Electrical and Electronics Engineering, Fukui University
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Izumori Ken
Rare Sugar Res. Center Kagawa Univ.
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Izumori Ken
Rare Sugar Research Center Kagawa University
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Izumori Ken
Department Of Biochemistry And Food Science Faculty Of Agriculture Kanagawa University
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Izumori Ken
Department Of Bioresource Science Faculty Of Agriculture Kagawa University
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Masada Tetsuya
Department Of Gastroenterology And Neurology Kagawa University School Of Medicine
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Takata Maki
Department Of Cell Physiology Faculty Of Medicine Kagawa University:teikoku Seiyaku Co. Ltd.
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Yamaguchi Fuminori
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Nakanose Koichi
Department of Cell Physiology, Faculty of Medicine, Kagawa University
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Tsukamoto Ikuko
Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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Nagata Mitsuhiro
Teikoku Seiyaku Co. Ltd.
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Tokuda M
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Masaki Tsutomu
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Watanabe Y
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Nakanose Koichi
Department Of Cell Physiology Faculty Of Medicine Kagawa University:kagawa Industry Support Foundati
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Tsukamoto Ikuko
Department Of Pharmaco-bio-informatics Faculty Of Medicine Kagawa University
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Tsukamoto Ikuko
Department Of Anesthesiology And Emergency Medicine Kagawa Medical School
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Watanabe Yasuo
Department Of Agricultural Chemistry College Of Agriculture Ehime University
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Yamaguchi Fuminori
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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Watanabe Yasuo
Institute of Space and Astronautical Science
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