Antimutagenic Effect of Amino Acids on the Mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
The antimutagenic activity of protein-constituting amino acids except histidine on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in vitro using Salmonella typhinurium TA-100 as an indicator bacterium (Ames test), and concentrations (IC_<50>) of amino acids that inhibit 50% of the mutagenecity were measured. Cysteine was found to be most active and glycine, tryptophan, lysine, and arginine were strong antimutagenic amino acids. Other amino acids showed moderate or weak antimutagenic activities, depending on the amino acids. The results indicate that amino acids play a substantial role in chemoprevention of N-nitroso amine-induced mutagenicity.
- 社団法人日本農芸化学会の論文
- 2002-06-23
著者
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Watanabe Yasuo
Department of Cardiology, Nihon University School of Medicine
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Watanabe Yasuo
Department Of Cardiology Nihon University School Of Medicine
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Watanabe Y
Department Of Bioresources Faculty Of Agriculture Ehime University
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KUWABARA YUJI
Shikoku Milk Product Co. Ltd.
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TAMAI YOUICHI
Department of Biological Resources, Faculty of Agriculture, Ehime University
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Tamai Y
Department Of Bioresources Faculty Of Agriculture Ehime University
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Tamai Youichi
Department Of Agricultural Chemistry College Of Agriculture Ehime University
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Watanabe Y
Department Of Cell Physiology Faculty Of Medicine Kagawa University
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ROY Molay
Department of Bioresource, Faculty of Agriculture, Ehime University
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HARA Kazusi
Shikoku Milk Product Co. Ltd.
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Roy Molay
Department Of Bioresource Faculty Of Agriculture Ehime University
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Watanabe Yasuo
Department Of Agricultural Chemistry College Of Agriculture Ehime University
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Watanabe Yasuo
Institute of Space and Astronautical Science
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