An Inhibitory Effect of Chrysoeriol on Platelet-Derived Growth Factor (PDGF)-Induced Proliferation and PDGF Receptor Signaling in Human Aortic Smooth Muscle Cells
スポンサーリンク
概要
- 論文の詳細を見る
Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders such as restenosis and atherosclerosis. Chrysoeriol is a flavonoid with antioxidant and anti-inflammatory activities. In this study, we investigated the effect of chrysoeriol on the proliferation of human aortic smooth muscle cells (HASMC). Chrysoeriol significantly inhibited PDGF (20 ng/mL)-induced migration and [3H]-thymidine incorporation into DNA at concentrations of 5 and 10 μM without any cytotoxicity. Chrysoeriol also blocked PDGF-stimulated dissociation of actin filament and inhibited PDGF beta-receptor (Rβ) phosphorylation in a concentration-dependent manner. As a result, the downstream signal transduction pathways of PDGF-Rβ, including ERK1/2, p38, and Akt phosphorylation, were also inhibited by chrysoeriol in the same pattern. These findings suggest that in addition to its antioxidant and anti-inflammatory activities, chrysoeriol may be used for the prevention and treatment of vascular diseases and during restenosis after coronary angioplasty.
- 社団法人 日本薬理学会の論文
- 2009-05-20
著者
-
Shi Wen
Department Of Biological Chemistry Chubu University
-
Cha Byung-yoon
Res. Inst. For Biological Functions Chubu Univ.
-
Yonezawa Takayuki
Research Institute for Biological Functions, Chubu University
-
Nagai Kazuo
Research Institute for Biological Functions, Chubu University
-
Woo Je-Tae
Research Institute for Biological Functions, Chubu University
-
CHA Byung-Yoon
Research Institute for Biological Functions, Chubu University
-
TERUYA Toshiaki
Research Institute for Biological Functions, Chubu University
-
Woo Je-tae
Dep. Of Biological Chemistry Chubu Univ.
-
Woo J‐t
Chubu Univ. Aichi Jpn
-
Woo Je-tae
Sagami Chemical Research Center
-
Woo Je-tae
Department Of Bioengineering Tokyo Institute Of Technology
-
Teruya Toshiaki
Res. Inst. For Biological Functions Chubu Univ.
-
Yonezawa Takayuki
Research Institute For Biological Functions Chubu University
-
Nagai Kazuo
Department Of Biological Chemistry Chubu University
-
Cha Byung-yoon
Research Institute For Biological Functions Chubu University
-
Nagai Kazuo
Research Institute For Biological Functions Chubu University
-
Teruya Toshiaki
Research Institute For Biological Functions Chubu University
関連論文
- Quercetin Suppresses Bone Resorption by Inhibiting the Differentiation and Activation of Osteoclasts (Pharmacology)
- Palmatine Attenuates Osteoclast Differentiation and Function through Inhibition of Receptor Activator of Nuclear Factor-κB Ligand Expression in Osteoblast Cells
- Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity
- An Inhibitory Effect of Chrysoeriol on Platelet-Derived Growth Factor (PDGF)-Induced Proliferation and PDGF Receptor Signaling in Human Aortic Smooth Muscle Cells
- Prodigiosin 25-C and Metacycloprodigiosin Suppress the Bone Resorption by Osteoclasts
- Concanamycin B, a Vacuolar H^+-ATPase Specific Inhibitor Suppresses Bone Resorption in Vitro
- Honokiol Inhibits Osteoclast Differentiation and Function in Vitro
- Phytochemicals That Stimulate Osteoblastic Differentiation and Bone Formation
- Pharmacological Topics of Bone Metabolism : Antiresorptive Microbial Compounds That Inhibit Osteoclast Differentiation, Function, and Survival
- Requirement of osteoblastic cells for the fusion of preosteoclasts
- Cathestatins, New Cysteine Protease Inhibitors Produced by Penicillium citrinum
- Characterization of the Nitrate-Nitrite Transporter of the Major Facilitator Superfamily (the nrtP Gene Product) from the Cyanobacterium Nostoc punctiforme Strain ATCC 29133
- Insulin-Dependent Adipogenesis in Stromal ST2 Cells Derived from Murine Bone Marrow(Biochemistry & Molecular Biology)
- Honokiol Increases ABCA1 Expression Level by Activating Retinoid X Receptor Beta
- Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes
- The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells
- N,N'-diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-L1 cells
- Discovery of novel rules for G-quadruplex-forming sequences in plants by using bioinformatics methods(BIOINFORMATICS)
- Discovery of novel rules for G-quadruplex-forming sequences in plants by using bioinformatics methods