Expression of the Heparin-Binding Growth Factor Midkine in the Cerebrospinal Fluid of Patients with Neurological Disorders
スポンサーリンク
概要
- 論文の詳細を見る
Objective This study was to clarify the roles of midkine (MK) in the brain. Methods We determined cerebrospinal fluid MK levels in patients with neurological disorders by enzyme-linked immunoassay and immunostained autopsied brain samples in patients with meningitis. Results MK levels were 0.37±0.21 ng/ml in controls (n=46, mean ± S.D.), 0.67±0.19 ng/ml in patients with cerebral infarction (n=8), 1.78±1.32 ng/ml in patients with meningitis (n=25; ANOVA and post-hoc Fisher's PLSD test, p<0.0001), 0.31±0.25 ng/ml in patients with human T-lymphotrophic virus type I-associated myelopathy/tropical spastic paraparesis (n=29), and 0.42±0.17 ng/ml in patients with amyotrophic lateral sclerosis (n=8). The regression equations were Y=0.005X+0.498 (Y, CSF MK level; X, cell number) and Y=0.007X+0.326 (Y, MK level; X, protein level) for all CSF samples. Autopsy brain samples from patients with meningitis expressed MK weakly in mononuclear cells on immunohistochemical examination. Western blot and polymerase chain reaction analyses showed that leukocytes were MK positive. CSF MK levels were not high in patients with cerebral infarction but were increased in patients with meningitis. CSF MK levels were high in normal controls, compared to those of other cytokines. MK was expressed in choroid plexus of normal brain and released there. Conclusion Our findings suggested that MK may maintain normal adult brain as a neurotrophic factor, and that MK may be released from leucocytes in brain of patients with meningitis as an immunological mediator.
著者
-
IKEMATSU Shinya
Meiji Cell Technology Center
-
Osame Mitsuhiro
Department Of Internal Medicine Faculty Of Medicine Kagoshima University
-
Muramatsu Hisako
Department Od Biochemistry Nagoya University School Of Medicine
-
Sakakima Harutoshi
School Of Health Sciences Faculty Of Medicine Kagoshima University
-
Umehara Fujio
Department Of Internal Medicine Iii Faculty Of Medicine Kagoshima University
-
Goto Masamichi
Department Of Human Pathology Field Of Oncology Kagoshima University Graduate School Of Medical And
-
Matsuda Fumiyo
School Of Medical Sciences Faculty Of Medicine Kagoshima University
-
Yoshida Yoshihiro
School Of Health Sciences Faculty Of Medicine Kagoshima University
-
Matsuura Eiji
Department Of Cell Chemistry Okayama University Graduate School Of Medicine Dentistry And Pharmaceutical Sciences
-
MURAMATSU Takashi
Department of Animal Breeding and Reproduction, Faculty of Agriculture Utsunomiya University
-
Mizuma Nobuhisa
Department of Neurology, Faculty of Medicine, Kagoshima University
-
Sonoda Ken
Kagoshima Medical Association Hospital
-
Ohkubo Ryuichi
Department of Neurology, Faculty of Medicine, Kagoshima University
-
Matsuura Eiji
Department of Neurology, Faculty of Medicine, Kagoshima University
-
Matsuda Fumiyo
School of Health Sciences, Faculty of Medicine, Kagoshima University
-
Muramatsu Takashi
Department of Biochemistry, School of Medicine, Nagoya University
関連論文
- PI-17 Epigenetic mechanism of MUC1, MUC2 and MUC4 gene expression related with outcome of human neoplasms
- An Immunohistochemical Analysis of Peripheral Blood Tissue Specimens from Leukemia Cells : Leukemic Cells of Adult T-cell Leukemia/Lymphoma Express p40Tax Protein of Human T-cell Lymphotropic Virus Type 1 When Entering Reproliferation
- Biological characteristics of the junctional epithelium
- PII-27 Immunohistological studies on the palatine rugae development in mice
- The expression and localization of osteopontin in the mouse major salivary glands
- The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels
- Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Aberrant expression of pyloric gland-type mucin in mucin-producing bile duct carcinomas : A clear difference between the core peptide and the carbohydrate moiety
- Immunohistochemical Localization of Pleiotrophin and Midkine in the Lingual Epithelium of the Adult Rat
- CHANGES IN ACTIVITIES OF DAILY LIVING,PHYSICAL FITNESS, AND DEPRESSIVE SYMPTOMS AFTER SIX-MONTH PERIODIC WELL-ROUNDED EXERCISE PROGRAMS FOR OLDER ADULTS LIVING IN NURSING HOMES OR SPECIAL NURSING FACILITIES
- Uric Acid and Left Ventricular Hypertrophy in Japanese Men
- Receptor-type protein tyrosine phosphatase ζ as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
- Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
- Frequent Expression of Midkine Gene in Esophageal Cancer Suggests a Potential Usage of Its Promoter for Suicide Gene Therapy
- Epstein-Barr virus-associated enteritis with multiple ulcers after stem cell transplantation : First histologically confirmed case
- ASSESSMENT OF MITOCHONDRIAL GENE IN PROLIFERATIVE VITREORETINAL TISSUES FROM PATIENTS WITH FAMILIAL DIABETES MELLITUS
- DIFFERENTIAL EXPRESSION OF mRNA FOR α2, 3-SIALYLTRANSFERASE DURING DEVELOPMENT OF RAT RETINA
- Does normal looking skin of pure neuritic leprosy reflect carrier status of Mycobacterium leprae? : Part (1)
- Presence of Mycobacterium leprae-specific antigen (PGL-I) and DNA in human central nervous system
- Uterine lipoleiomyoma : A histopathological review of 17 cases
- REVIEW OF HISTOPATHOLOGY IN A SPECIAL SKIN CLINIC IN YANGON, MYANMAR
- Expression of Different Glycoforms of Membrane Mucin (MUC1) and Secretory Mucin (MUC2, MUC5AC and MUC6) in Pancreatic Neoplasms(Prof. K Watanabe Memorial Article)
- PJ-525 The Acute and Late Outcome of Sirolimus-eluting Stent(SES) in Small Coronary Arteries Comparing with Bare-Metal Stent(BMS)(Coronary revascularization, PCI-19 (IHD) PJ88,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- PJ-519 Late Outcome of Drug Eluting Stent (DES) in the High Restenosis Factors in Bare Metal Stent (BMS) Era(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- PJ-358 8 Month-outcome of Very Long (>36mm) Silolimus-eluting-stent Implanted Segments(Coronary revascularization, PCI-16 (IHD) PJ61,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-083 Midkine Ameliorates Ischemia/Reperfusion Injury of Cardiac Muscle through a Reduction of Apoptotic Reaction(Myocardial Ischemia-Reperfusion, Basic and Clinical 1 (IHD) : OE10)(Oral Presentation (English))
- Human N-Acetylglucosamine-6-O-Sulfotransferase Involved in the Biosynthesis of 6-Sulfo Sialy Lewis X : Molecular Cioning, Chromosomal Mapping, and Expreeion in Various Organs and Tumor Cells
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity^1
- Le^X Structure Enhances Myocardial Differentiation from Embryonic Stem Cells
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas
- PJ-518 Acute and Late Outcome of Sirolimus Eluting Stent in Bifurcation Lesions Comparing with Bare Metal Stent(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulat
- Glycoconjugate Histochemistry of Membranous Structures of NASU Disease
- Retroperitoneal uterine leiomyoma occurring 5 years after hysterectomy for fibroids
- Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
- Expression of Syndecan-1 and -3 during Embryogenesis of the Central Nervous System in Relation to Binding with Midkine^1
- Midkine Expression is Associated with Postnatal Development of the Lungs
- Distinct expression of midkine and pleiotrophin in the spinal cord and placental tissues during early mouse development
- Embigin/basigin subgroup of the immunoglobulin superfamily : Different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers
- Restricted Expression of Xenopus Midkine Gene during Early Development
- PE-409 High-density Lipoprotein Cholesterol as a Biomarker to Predict Risk for Myocardial Infarction in Working Population(PE069,Preventive Medicine/Epidemiology/Education 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese C
- OE-069 Adiponectin as a Potential Biomarker to Predict Risk for Myocardial Infarction in Male Working Population(OE12,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Socie
- PJ-760 Obesity as a Major Risk Factor for Acute Myocardial Infarction in Japanese working age(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Soc
- A Novel Truncated Variant Form of Ebk/MDK1 Receptor Tyrosine Kinase Is Expressed in Embryonic Mouse Brain
- Midkine, a Heparin-Binding Growth/Differentiation Factor, Exhibits Nerve Cell Adhesion and Guidance Activity for Neurite Outgrowth In Vitro
- Expression of MUC1 and MUC2 mucins in extrahepatic bile duct carcinomas: Its relationship with tumor progression and prognosis
- MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma
- Expression of MUC1 and MUC2 mucins and relationship with cell proliferative activity in human colorectal neoplasia
- Molecular Cloning and Expression of Endo-β-N-Acetylglucosaminidase D, Which Acts on the Core Structure of Complex Type Asparagine-Linked Oligosaccharides^1
- The Ratio of Splicing Variants of MGC-24/CD164, a Sialomucin, Correlates with the Metastatic Protential of Colorectal Carcinomas
- Structure of the Mouse Basigin Gene, a Unique Member of the Immunoglobulin Superfamily
- cDNA Cloning and Sequence Analysis of a Novel Calcium Binding Protein with Oligoproline Motif
- CBP-140, a Novel Endoplasmic Reticulum Resident Ca^-binding Protein with a Carboxy-terminal NDEL Sequence Showed Partial Homology with 70-kDa Heat Shock Protein (hsp70)
- Zep: A Novel Zinc Finger Protein Containing a Large Proline-Rich Domain
- Antigenic structures recognized by anti-β2-glycoprotein I auto-antibodies
- Anti-β_2-glycoprotein I antibodies in children with atopic dermatitis
- Mucin expression profile in pancreatic cancer and the precursor lesions
- IIB-02 MUC4 expression correlates with poor prognosis in lung adenocarcinoma(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- PE-557 Association of Insulin Resistance with Habitual Dietary Intake of Fatty Acids among Middle-aged Japanese Men(Preventive medicine/Epidemiology/Education(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- Immunologic characterization and functional properties of murine antibodies raised against deleted mutants of human β_2-glycoprotein I
- Mutation analysis of Japanese patient with fucosidosis
- Difference in the relative contribution of lean and fat mass components to bone mineral density with generation
- Stage-Specific Localization of Basigin, a Member of the Immunoglobulin Superfamily, During Mouse Spermatogenesis
- Midkine Counteracts the Activin Signal in Mesoderm Induction and Promotes Neural Formation^1
- ES細胞の糖鎖マーカー
- The Trial Development of an Original C-Shaped Cervical Collar (Kagoshima-Sekijyuji, KS Collar) for Patients with Rheumatoid Arthritis
- Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor β-1
- Midkine Enhances Early Stages of Collagen Gel Contraction^1
- Expression Profile of Mouse BWF1, a Protein with a BEACH Domain, WD40 Domain and FYVE Domain
- Midkine (MK) Expression in Extraembryonic Tissues, Amniotic Fluid, and Cerebrosphinal Fluid during Mouse Embryogenesis
- Mutational analysis of MECP2 in Japanese patients with atypical Rett syndrome
- Increased Serum Midkine Levels during Hemodialysis Using Heparin in Chronic Renal Failure
- II-C-12 The reduced expression of capillary tight junction comprised proteins in a patient with myopathy(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Circulating levels of MMP-1, -2, -3, -9, and TIMP-1 are increased in POEMS syndrome
- Midkine Rescues Wilms' Tumor Cells from Cisplatin-Induced Apoptosis: Regulation of Bcl-2 Expression by Midkine^1
- II-C-10 Midkine Expression in rat degenerative and regenerative muscle fibers after ischemic injury(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- CHANGES AT THE NEUROMUSCULAR JUNCTIONS IN THE AFFECTED MUSCLES OF NEOSTIGMINE-TREATED RATS, TENOTOMIZED RATS AND A PATIENT WITH NEMALINE MYOPATHY (SYMPOSIUM ON HISTOCHEMISTRY AND CYTOCHEMISTRY OF NEUROTRANSMITTERS AND ITS CLINICAL APPLICATION)
- A Patient with Acute-Onset HAM/TSP after Blood Transfusion Complicated with Pseudopseudohypo-parathyroidism
- Practical and Safe Sulfonylation of 2-Alkynyl and 2-Alkenyl Alcohols Using the Combined Bases of a Catalytic Amount of Tertiary Amine and Potassium Carbonate
- Midkine, a Retinoic Acid-Inducible Heparin-Binding Cytokine in Inflammatory Responses: Chemotactic Activity to Neutrophils and Association with Inflammatory Synovitis
- Effects of Immobilization and Subsequent Low and High Frequency Treadmill Running on Rat Soleus Muscle and Ankle Joint Movement
- Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells
- Immunohistochemical study of mucin expression in periampullary adenomyoma
- Significance of mucin expression in pancreatobiliary neoplasms
- An Approach to the Removal of Yeast Specific O-Linked Oligo-Mannoses from Human Midkine Expressed in Pichia pastoris Using Site-Specific Mutagenesis
- Iodine-123 iodobenzofuran (I-123 IBF) SPECT in patients with parkinsonism
- Effects of Long-Term Denervation and Subsequent Reinnervation on Leg Muscles and Bones of Rats
- A Splicing Factor, Prp8 : Preferential Localization in the Testis and Ovary in Adult Mice
- Hyponatremia Upon Resumption of Paroxetine Therapy
- The Effect of Short Duration Static Stretching and Reinnervation on the Recovery of Denervated Soleus Muscle in the Rat
- The Effect of Denervation and Subsequent Reinnervation on the Morphology of Rat Soleus Muscles
- Isokinetic trunk and knee muscle strengths and gait performance in walking patients with T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
- Recombinant domain V of β_2-glycoprotein I inhibits the formation of a 7-ketocholesteryl-9-carboxynonanoate and β_2-glycoprotein I complex
- Expression of mucin antigens (MUC1 and MUC16) as a prognostic factor for mucinous adenocarcinoma of the uterine cervix
- Expression of the Heparin-Binding Growth Factor Midkine in the Cerebrospinal Fluid of Patients with Neurological Disorders
- An experimental model of nephritis induced by calf serum injection in mice.
- Molecular Cloning and Expression of Endo-.BETA.-N-Acetylglucosaminidase D, Which Acts on the Core Structure of Complex Type Asparagine-Linked Oligosaccharides.
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas.
- Zep: A Novel Zinc Finger Protein Containing a Large Proline-Rich Domain.
- Midkine Enhances Early Stages of Collagen Gel Contraction.
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity.