Midkine Enhances Early Stages of Collagen Gel Contraction.
スポンサーリンク
概要
- 論文の詳細を見る
Midkine (MK) is a heparin-binding growth/differentiation factor implicated in the control of development and repair of various tissues. To investigate the roles of MK in embryogenesis and in regulation of wound healing, we utilized a system of collagen gel contraction by dermal fibroblasts, which provides an in vitro model for studying fibroblast-collagen interactions important in various physiological and pathological phenomena. MK enhanced gel contraction 8-24 h after plating, and its effect was inhibited by anti-MK antibody. The effect was reduced after 48 h, while TGF-β continued to be active in the later stage. Morphologically, MK-treated fibroblasts tended to be elongated more frequently than control fibroblasts. The effect of MK in the early stage of gel contraction suggests a role of MR as a modulator of cell-matrix interactions.
- 社団法人 日本生化学会の論文
著者
-
Muramatsu Hisako
Department Od Biochemistry Nagoya University School Of Medicine
-
Ueda Minoru
Department 1 Product Development Division 1 Motorcycle R&d Center Honda R&d Co. Ltd.
-
Hata Ken-ichiro
Department of Oral and Maxillofacial Surgery, Nagoya University School of Medicine
-
MURAMATSU Takashi
Department of Animal Breeding and Reproduction, Faculty of Agriculture Utsunomiya University
-
Sumi Yukio
Department of Biochemishy Nagoya University School of Medicine
関連論文
- Efficacy of Membranous Cultured Periosteum for the Treatment of Patients with Severe Periodontitis: a Proof-of-Concept Study
- Biological characteristics of the junctional epithelium
- PII-27 Immunohistological studies on the palatine rugae development in mice
- The expression and localization of osteopontin in the mouse major salivary glands
- The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels
- Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Decellularized ureter for tissue-engineered small-caliber vascular graft
- Effective Cell-Seeding Technique Using Magnetite Nanoparticles and Magnetic Force onto Decellularized Blood Vessels for Vascular Tissue Engineering(CELL AND TISSUE ENGINEERING)
- Immunohistochemical Localization of Pleiotrophin and Midkine in the Lingual Epithelium of the Adult Rat
- CHANGES IN ACTIVITIES OF DAILY LIVING,PHYSICAL FITNESS, AND DEPRESSIVE SYMPTOMS AFTER SIX-MONTH PERIODIC WELL-ROUNDED EXERCISE PROGRAMS FOR OLDER ADULTS LIVING IN NURSING HOMES OR SPECIAL NURSING FACILITIES
- Uric Acid and Left Ventricular Hypertrophy in Japanese Men
- Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. MK929-43F1
- Receptor-type protein tyrosine phosphatase ζ as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons
- P-37 Fluorescence Studies on the Nyctinasty of Albizzia Plants, An enantio-differential approach Using Enantio-pair of Fluorescence-labeled leaf closing factors
- Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma
- Frequent Expression of Midkine Gene in Esophageal Cancer Suggests a Potential Usage of Its Promoter for Suicide Gene Therapy
- THE INDUCTION OF DENTIN BRIDGE-LIKE STRUCTURES BY CONSTRUCTS OF SUBCULTURED DENTAL PULP-DERIVED CELLS AND POROUS HA/TCP IN PORCINE TEETH
- Differential Inducibility of Human and Porcine Dental Pulp-Derived Cells into Odontoblasts
- Case-Control Study of Oral Cancer in Shenyang, Northeastern China
- Long-term results of osseointegrated implant-retained facial prostheses: a 5-year retrospective study
- DIFFERENTIAL EXPRESSION OF mRNA FOR α2, 3-SIALYLTRANSFERASE DURING DEVELOPMENT OF RAT RETINA
- Fate of transplanted nail matrical cells and potential of hard keratin production in vivo
- The effect of the long-term cultivation on telomere length and morphology of cultured epidermis
- Incorporation of Capillary-Like Structures into Dermal Cell Sheets Constructed by Magnetic Force-Based Tissue Engineering
- Selective hyperthermia using magnetoliposomes to target cervical lymph node metastasis in a rabbit tongue tumor model
- Proliferation and Stratification of Keratinocyte on Cultured Amniotic Epithelial Cells for Tissue Engineering(MEDICAL BIOTECHNOLOGY)
- Transglutaminase-Mediated Gelatin Matrices Incorporating Cell Adhesion Factors as a Biomaterial for Tissue Engineering
- Suicide gene therapy using adenovirus vector for human oral squamous carcinoma cell line In vitro
- Assesment of the Effects of Aging and Medication on Salivary Gland Function in Patients with Xerostomia Using Tc^-Scintigraphy
- The Localization of Basic Fibroblast Growth Factor (FGF-2) in Rat Submandibular Glands
- PJ-525 The Acute and Late Outcome of Sirolimus-eluting Stent(SES) in Small Coronary Arteries Comparing with Bare-Metal Stent(BMS)(Coronary revascularization, PCI-19 (IHD) PJ88,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- PJ-519 Late Outcome of Drug Eluting Stent (DES) in the High Restenosis Factors in Bare Metal Stent (BMS) Era(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- PJ-358 8 Month-outcome of Very Long (>36mm) Silolimus-eluting-stent Implanted Segments(Coronary revascularization, PCI-16 (IHD) PJ61,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-083 Midkine Ameliorates Ischemia/Reperfusion Injury of Cardiac Muscle through a Reduction of Apoptotic Reaction(Myocardial Ischemia-Reperfusion, Basic and Clinical 1 (IHD) : OE10)(Oral Presentation (English))
- Human N-Acetylglucosamine-6-O-Sulfotransferase Involved in the Biosynthesis of 6-Sulfo Sialy Lewis X : Molecular Cioning, Chromosomal Mapping, and Expreeion in Various Organs and Tumor Cells
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity^1
- Le^X Structure Enhances Myocardial Differentiation from Embryonic Stem Cells
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas
- PJ-518 Acute and Late Outcome of Sirolimus Eluting Stent in Bifurcation Lesions Comparing with Bare Metal Stent(Coronary revascularization, PCI-18 (IHD) PJ87,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulat
- Highly Sensitive Determination of Cadmium and Lead in Leached Solutions from Ceramic Ware by Graphite Furnace Atomic Absorption Spectrometry Coupled with Sequential Injection-based Solid Phase Extraction Method
- Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N-Nitrosobis(2-oxopropyl)amine in Hamsters and Their Cell Lines
- Expression of Syndecan-1 and -3 during Embryogenesis of the Central Nervous System in Relation to Binding with Midkine^1
- Development of Integrated Fuel Injection System for Small Sized Motorcycles
- Molecular Cloning and Expression of Endo-β-N-Acetylglucosaminidase D, Which Acts on the Core Structure of Complex Type Asparagine-Linked Oligosaccharides^1
- Antibacterial Activities of New Synthetic Divalent Cation Chelators
- cDNA Cloning and Sequence Analysis of a Novel Calcium Binding Protein with Oligoproline Motif
- CBP-140, a Novel Endoplasmic Reticulum Resident Ca^-binding Protein with a Carboxy-terminal NDEL Sequence Showed Partial Homology with 70-kDa Heat Shock Protein (hsp70)
- Zep: A Novel Zinc Finger Protein Containing a Large Proline-Rich Domain
- Primary Clinical Effects of PP Therapy (Cisplatin and Peplomycin) and TPP Therapy (4^1-O-tetrahydropyranyladriamycin, Cisplatin and Peplomycin) for Oral Cancer
- Intracellular Localization and Partial Amino Acid Sequence of a Stress-Inducible 40-kDa Protein in HeLa Cells
- Sonic Hedgehog cDNA-plasmid Vector Transduction by Microbubble-Enhanced Sonoporation for Ectopic Bone Formation
- Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity
- Receptor for Hyaluronan-mediated Motility and CD44 Expressions in Colon Cancer Assessed by Quantitative Analysis Using Real-time Reverse Transcriptase-Polymerase Chain Reaction
- Arrangement of D-Periodic Collagen Fibrils and Association of Proteoglycans with Fibrils in the Synovium of the Mouse Temporomandibular Joint
- ES細胞の糖鎖マーカー
- Experimental Study of Tissue Engineered Bone Using Biodegradable Ceramic β-TCP as Scaffold
- Thrombospondin-1 promotes fibroblast-mediated collagen gel contraction caused by activation of latent transforming growth factor β-1
- Midkine Enhances Early Stages of Collagen Gel Contraction^1
- Expression Profile of Mouse BWF1, a Protein with a BEACH Domain, WD40 Domain and FYVE Domain
- Cell Death of Human Oral Squamous Cell Carcinoma Cell Line Induced by Herpes Simplex Virus Thymidine Kinase Gene and Ganciclovir
- Tissue-Engineered Bone Using Mesenchymal Stem Cells and a Biodegradable Scaffold
- Bone Regeneration Method Using Mesenchymal Stem Cells (MSCs) and Platelet-Rich Plasma (PRP) Complexes for Sinus Floor Elevation in Rabbits
- Expression of Odontoblastic-Related Genes in Human Dental Follicle Cells, Dental Pulp Stem Cells, and Oral Mucosal Cells
- A comparison of osteogenesis-related gene expression of mesenchymal stem cells during the osteoblastic differentiation induced by Type-I collagen and/or fibronectin
- Effect of the Combination of a Local OK-432 Injection and Hyperthermia on SCC VII Tumors in Mice
- Increased Serum Midkine Levels during Hemodialysis Using Heparin in Chronic Renal Failure
- ORAL INJURY AND THE USE OF MOUTH GUARDS - SOCCER, RUGBY, BASKETBALL PLAYER IN JAPANESE HIGH SCHOOL-
- Cotranslocation and Colocalization of hsp40 (DnaJ) with hsp70 (DnaK) in Mammalian Cells
- Three-dimensional computed tomographic analysis for placement of maxillofacial implants after maxillectomy.
- A quantitative study of nerve fiber density in the submandibular gland of rats
- Tissue-Engineered Composites of Anulus Fibrosus and Nucleus Pulposus for Intervertebral Disc Replacement
- P-33 DEVELOPMENT OF CHEMICAL LABELING METHODS FOR PURIFICATION OF THE RECEPTOR PROTEINS CONCERNING NYCTINASTY
- Bacteriological Evaluation of a New Air Turbine Handpiece for Preventing Cross-Contamination in Dental Procedures
- Evidence That Escherichia coli ubiA Product Is a Functional Homolog of Yeast COQ2, and the Regulation of ubiA Gene Expression
- Leaf-opening Substance in the Nyctinastic Plant, Albizzia julibrissin Durazz
- The Enzymatic Transformation of Leaf-Movement Factor in Lespedeza cuneata G.Don Controlled by a Biological Clock
- Changes in Intracellular Ca^ Concentration Produced by the Alteration of Intracellular pH in Rat Parotid Acinar Cells
- Midkine, a Retinoic Acid-Inducible Heparin-Binding Cytokine in Inflammatory Responses: Chemotactic Activity to Neutrophils and Association with Inflammatory Synovitis
- Gingival and dermal fibroblasts : Their similarities and differences revealed from gene expression(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- マメ科植物の就眠運動を制御する配糖体型生理活性物質のケミカルバイオロジー
- Synthesis and Bioactivity of Potassium β-D-Glucopyranosyl 12-Hydroxy Jasmonate and Related Compounds
- Formation of Epithelial Sheets by Serially Cultivated Human Mucosal Cells and Their Applications as a Grart Material
- Synthesis of Staudinger-type Molecular Probe for Catch-and-release Purification of the Binding Protein for Potassium Isolespedezate, a Leaf-closing Substance of Leguminous Plant
- P-40 NANOMETER-SCALE DIRECT OBSERVATION OF THE RECEPTOR CONCERNING NYCTINASTY, USING MOLECULAR PROBE FOR ELECTRON MICROSCOPY
- The hypertrophic chondrocytes of the bone morphogenetic protein induced cartilage
- Regulation of the Wnt Signaling Pathways during Cell Culture of Human Mesenchymal Stem Cells for Efficient Bone Regeneration
- The Clinical and Histopathological Effects of Combined Chemotherapy Using Cisplatin and Peplomycin to Treat Cancer of the Tongue
- Leiomyosarcoma of the Maxillary Gingiva : A Case Report
- A Splicing Factor, Prp8 : Preferential Localization in the Testis and Ovary in Adult Mice
- Double Fluorescence-labeling Study on Genus Albizzia Using a Set of Fluorecence-labeled Leaf-movement Factors to Identify the Spatial Distribution of Their Receptors
- P-41 AFFINITY PURIFICATION OF β-GLUCOSIDASE, THE KEY ENZYME CONTROLLING NYCTINASTIC MOVEMENT OF LEGUMINOUS PLANTS
- Chemical Basis of Plant Leaf Movement
- Spatial image of school environment in children with cleft lip and/or palate
- Maxillofacial Bone Regeneration Using Tissue Engineering Concepts
- Expression of the Heparin-Binding Growth Factor Midkine in the Cerebrospinal Fluid of Patients with Neurological Disorders
- Molecular Cloning and Expression of Endo-.BETA.-N-Acetylglucosaminidase D, Which Acts on the Core Structure of Complex Type Asparagine-Linked Oligosaccharides.
- Enzyme-Linked Immunoassay for Midkine, and Its Application to Evaluation of Midkine Levels in Developing Mouse Brain and Sera from Patients with Hepatocellular Carcinomas.
- Zep: A Novel Zinc Finger Protein Containing a Large Proline-Rich Domain.
- Midkine Enhances Early Stages of Collagen Gel Contraction.
- Clusters of Basic Amino Acids in Midkine: Roles in Neurite-Promoting Activity and Plasminogen Activator-Enhancing Activity.