Effect of the Combination of a Local OK-432 Injection and Hyperthermia on SCC VII Tumors in Mice
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概要
- 論文の詳細を見る
Hyperthermia is being investigated as a cancer treatment. Many of its basic mechanisms, particularly those related to cell killing, are still poorly understood. We used a transplanted squamous cell carcinoma cell line to investigate the therapeutic effect of hyperthermia. In particular, we examined the effect of OK-432 (biological response modifier) on hyperthermia-induced apoptosis. In the hyperthermia only group the most extensive necrosis occurred on day 3 (70.3%), and the apoptosis index also was highest on that day (69.3). These results suggest that the induction of apoptosis is closely related to the cell death caused by hyperthermia. The percent of necrosis was significantly higher in the groups given hyperthermia and combined OK-432 and hyperthermia treatment than in the OK-432 group (p<0.05). The apoptosis index was significantly lower in the combined OK-432 and hyperthermia treatment group than in the hyperthermia only group, indicative that the antitumor effect of combined hyperthermia and OK-432 therapy is not ascribable to the induction of apoptosis.
- 日本放射線影響学会の論文
著者
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HAYASHI Yasushi
Department of Energy Sciences, Tokyo Institute of Technology
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Ueda Minoru
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
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ITO Masafumi
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
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Ueda M
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Hayashi Yuko
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute Kanokoden
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TOHNAI Iwai
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
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Tohnai Iwai
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Ueda Minoru
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Ueda M
Department Of Oral Surgery Nagoya University School Of Medicine
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Hayashi Y
Central Laboratory And Radiation Biology Aichi Cancer Center Research Institute Kanokoden
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Ueda M
Department Of Cardiac Surgery Nagoya University Graduate School Of Medicine
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Ueda Minoru
Univ. Tokyo Jpn
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Yamada T
National Cancer Center Res. Inst. Tokyo Jpn
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Hayashi Yasushi
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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YAMADA TAKEHISA
Department of Oral Surgery, Nagoya University School of Medicine
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KANEKO RYUJI
Department of Oral Surgery, Nagoya University School of Medicine
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Ito Masafumi
Department Of Electrical And Electronic Engineering Faculty Of Science And Technology Meijo Universi
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Hayashi Y
Department Of Oral And Maxillofacial Surgery Nagoya University Graduate School Of Medicine
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Kaneko Ryuji
Department Of Oral Surgery Nagoya University School Of Medicine
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Ueda Minoru
Department Of Chemistry Faculty Of Science Tohoku University
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Ueda Minoru
Department Of Applied Chemistry Aichi Institute Of Technology
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Hayashi Yasushi
Department Of Energy Sciences Tokyo Institute Of Technology
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Ueda Minoru
Department 1 Product Development Division 1 Motorcycle R&d Center Honda R&d Co. Ltd.
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ITO Masafumi
Department of Pathology, Nagoya University Hospital
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