Azido-Coronatine: A Useful Platform for “Click Chemistry”-Mediated Probe Synthesis for Bioorganic Studies
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概要
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We report on the development of azide-coronatine as a useful platform for azide alkyne cycloaddition (“click chemistry”)-mediated synthesis of molecular probes. (+)-Azido-coronatine was synthesized in 10 steps with 11% yield using improved synthesis of coronafacic acid, in which the highly exo-selective Diels-Alder reaction (endo:exo > 1:25) is the key step. Azido coronatine was as effective as the original coronatine in a stomatal opening assay, and was easily modified to a fluorescein isothiocyanate (FITC)-labeled probe with high yield.
- 社団法人 日本農芸化学会の論文
著者
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Okada Masahiro
Department of Advanced Interdisciplinary Sciences, Graduate School of Engineering, Utsunomiya Univer
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Ueda Minoru
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine
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EGOSHI Syuusuke
Department of Chemistry, Tohoku University
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