Fluorescent In Situ Hybridization 1p/19q Deletion/Imbalance Analysis of Low-Grade and Atypical Meningiomas
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概要
- 論文の詳細を見る
The chromosomal 1p/19q state was analyzed in 16 low-grade meningiomas and 7 atypical meningiomas using fluorescent in situ hybridization (FISH) analysis. Chromosome 1p aberrations were observed in all atypical meningiomas, but in only one low-grade meningioma. Atypical meningiomas showed 19q deletion or imbalance, suggesting chromosomal instability of 19q. A small group of low-grade meningioma showed 19q aberrations. FISH 1p/19q deletion/imbalance analysis is a sensitive method for detecting chromosome aberrations of meningiomas and provides useful information for grading of meningiomas. Patients with low-grade meningioma with chromosomal instability of 1p/19q should be followed up carefully. Assessment of the chromosomal state by FISH might be of crucial importance in the clinical management of meningiomas.
- 社団法人 日本脳神経外科学会の論文
- 2010-01-15
著者
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NAGASAKA Toru
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital
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INAO Suguru
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital
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IKEDA Hiroshi
Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital
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Hayashi Kumiko
Chromosome Testing Group Molecular Genetic Testing Department Clinical Testing Center Mitsubishi Che
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GUNJI Masaharu
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
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HOSOKAI Noboru
Chromosome Testing Group, Molecular Genetic Testing Department, Clinical Testing Center, Mitsubishi
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FUJINO Masahiko
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
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ITO Masafumi
Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
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Inao Suguru
Department Of Neurosurgery Japanese Red Cross Nagoya Daiichi Hospital
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Nagasaka Toru
Department Of Neurosurgery Japanese Red Cross Nagoya Daiichi Hospital
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Hosokai Noboru
Chromosome Testing Group Molecular Genetic Testing Department Clinical Testing Center Mitsubishi Che
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Gunji Masaharu
Department Of Pathology Japanese Red Cross Nagoya Daiichi Hospital
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Fujino Masahiko
Department Of Pathology Japanese Red Cross Nagoya Daiichi Hospital
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Ito Masafumi
Department Of Pathology Japanese Red Cross Nagoya Daiichi Hospital
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Ito Masafumi
Department Of Electrical And Electronic Engineering Faculty Of Science And Technology Meijo Universi
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Fujino Masahiko
Department Of Pathology Japan Red Cross Nagoya 1^<st> Hospital
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Ikeda Hiroshi
Department Of Neurosurgery Japanese Red Cross Nagoya Daiichi Hospital
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Ikeda Hiroshi
Department Of Applied Chemistry Graduate School Of Engineering Osaka Prefecture University
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IKEDA HIROSHI
Deparment of Biology, Faculty of Science, Tokyo Metropolitan University
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