Upregulation of Heme Oxygenase-1 in an Animal Model of Takotsubo Cardiomyopathy
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概要
- 論文の詳細を見る
Background: Disturbance of the coronary microcirculation and catecholamine intoxication, which may be responsible for the pathogenesis of takotsubo cardiomyopathy, could trigger an oxidative stress response in the heart. Methods and Results: Expression and localization of inducible heme oxygenase-1 (HO-1), which is an oxidative stress-related factor in the heart of immobilization stressed (IMO) rats, an animal model of takotsubo cardiomyopathy, were investigated by real-time reverse transcriptase-polymerase chain reaction and in situ hybridization histochemistry and immunohistochemistry. In response to IMO, the levels of HO-1 mRNA in the heart and in the aorta were slightly increased at 90 min, and increased 3-fold at 3 h compared with control levels. The signals for HO-1 mRNA were expressed on scatted cells in the myocardium and aortic adventitia. Double fluorescence immunohistochemistry showed that HO-1 immunoreactive cells were also ED1 and ED2 positive, indicating that they were macrophages. The numbers of ED1 and ED2 positive cells were constant, whereas the number of HO-1 positive cells was increased 5-fold at 6 h compared with control levels. Blocking of α- and β-adrenoceptors attenuated IMO-induced upregulation of HO-1 mRNA levels in the heart. Conclusions: Emotional stress and a surge of catecholamine upregulate HO-1 in the cardiac and aortic macrophages. (Circ J 2009; 73: 1141-1146)
- 社団法人 日本循環器学会の論文
- 2009-05-20
著者
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ICHINOSE Masao
Second Department of Internal Medicine, Wakayama Medical University
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KIMURA Hiroko
Department of Forensic Medicine, Juntendo University School of Medicine
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Yoshida Ken-ichi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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UEYAMA Takashi
Departments of Anatomy and Cell Biology, Wakayama Medical University
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Hano Takuzo
Department Of Cardiovascular Medicine Wakayama Medical University
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Hano Takuzo
和歌山県立医科大学 解剖学第一
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Hano Takuzo
Center For Educational Research And Development Wakayama Medical University School Of Medicine
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Inoue M
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Ichinose M
Second Department Of Internal Medicine Wakayama Medical University
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Ueyama Takashi
Department Of Anatomy And Cell Biology Wakayama Medical University
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Ueyama T
Laboratory Of Food Chemistry Department Of Bioscience And Biotechnology Division Of Bioresource And
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Ichinose Masao
東京大学 医学系研究科消化器内科学
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Ichinose Masao
2nd Department Of Internal Medicine Wakayama Medical University
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Ichinose Masao
Second Department Of Internal Medicine Wakayama Medical University
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Ueda Kazuki
Second Department of Internal Medicine, Wakayama Medical University
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Tsuruo Yoshihiro
Department of Anatomy and Cell Biology, Wakayama Medical University
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Ueyama Takashi
Department Of Anatomy And Cell Biology Wakayama Medical University School Of Medicine
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UEDA Kazuki
2nd Department of Internal Medicine, Wakayama Medical University
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Hano Takuzo
School Of Allied Health Sciences Faculty Of Medicine Osaka University
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Ichinose M
Laboratory Of Pathology Aichi Cancer Center Research Institute
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Uehara Takashi
Department Of Anatomy And Cell Biology Wakayama Medical University
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KAWABE Tetsuya
Center for Educational Research and Development, Wakayama Medical University School of Medicine
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Ueda Kazuki
2nd Department Of Internal Medicine Wakayama Medical University
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Kimura Hiroko
Department Of Forensic Medicine Juntendo University School Of Medicine
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Kawabe Tetsuya
Center For Educational Research And Development Wakayama Medical University School Of Medicine
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Uehara Takashi
School Of Allied Health Sciences Osaka University Faculty Of Medicine
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Hano Takuzo
和歌山県立医科大学 循環器内科
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Yoshida Kenichi
Department Of Legal Medicine Graduate School Of Medicine University Of Tokyo
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Yoshida Ken-ichi
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
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Hirano Takashiro
School Of Allied Health Sciences Faculty Of Medicine Osaka University
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Uehara Takashi
Department Of Anatomy And Cell Biology Wakayama Medical University School Of Medicine
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Tsuruo Yoshihiro
Department Of Anatomy And Cell Biology Wakayama Medical University
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Tsuruo Y
Department Of Anatomy And Cell Biology Wakayama Medical University
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Kimura Hiroko
Department of Chemistry, Faculty of Science, Ochanomizu University
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