Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats
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概要
- 論文の詳細を見る
Background: Connexin-43 (Cx43) expression is reduced or redistributed in heart disease. Restraint or other emotional stressors might cause sudden death in persons with such diseases, but the mechanism of death and its connection to Cx43 during restraint remain unknown. Whether Cx43 distribution or gap junction (GJ) function during restraint is involved in sudden arrhythmic death in rats is addressed in this study. Methods and Results: Male Sprague - Dawley rats underwent immobilization (IMO), and individual electrocardiographic responses were monitored by telemetry. Heart sections were used to examine ventricular Cx43 distribution, and GJ intercellular communication (GJIC) activity was assessed using a dye-transfer assay. IMO induced the translocation of Cx43 into to the GJ-rich fraction, with a peak at 60 min. During IMO, Cx43 immunofluorescence was enhanced at intercalated discs, in association with GJIC activation, and premature ventricular contractions (PVCs) increased. In the presence of the GJ inhibitor, carbenoxolone (0.25 mg·kg-1·h-1), IMO induced lethal ventricular tachycardia or fibrillation in 21.7% of rats, in association with QRS prolongation and increased PVCs. Conclusions: IMO causes Cx43 translocation to intercalated discs, thereby reducing vulnerability to lethal arrhythmias via enhancing GJ coupling.
- 2010-05-25
著者
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KUWAHARA Masayoshi
Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U
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Yoshida Ken-ichi
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
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UNUMA Kana
Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo
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SHINTANI ISHIDA
Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo
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TSUSHIMA Kensuke
Department of Cardiovascular Medicine, University of Tokyo Hospital
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SHIMOSAWA Tatsuo
Department of Clinical Laboratory, Faculty of Medicine, University of Tokyo
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UEYAMA Takashi
Departments of Anatomy and Cell Biology, Wakayama Medical University
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Shintani Ishida
Department Of Forensic Medicine Graduate School Of Medicine University Of Tokyo
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Unuma Kana
Department Of Forensic Medicine Graduate School Of Medicine University Of Tokyo
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Unuma Kana
Department Of Forensic Medicine Graduate School Of Medicine The University Of Tokyo
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Ueyama Takashi
Department Of Anatomy And Cell Biology Wakayama Medical University
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Ueyama Takashi
Departments Of Anatomy And Cell Biology Wakayama Medical University
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences Universi
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
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Tsushima Kensuke
Department Of Cardiovascular Medicine University Of Tokyo
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Tsushima Kensuke
Department Of Cardiovascular Medicine University Of Tokyo Hospital
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Shimosawa Tatsuo
Department Of Clinical Laboratory Faculty Of Medicine University Of Tokyo
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Yoshida Ken-ichi
Department Of Forensic Medicine Graduate School Of Medicine University Of Tokyo
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Yoshida Ken-ichi
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
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SHINTANI-ISHIDA Kaori
Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences Universi
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Shimosawa Tatsuo
Department Of Aging Control Medicine Juntendo University Graduate School Of Medicine
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YOSHIDA Ken-ichi
Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo
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