Histamine-Induced Airway Contraction in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs

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概要

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• Airway hyper-responsiveness is known as an important pathogenesis of asthma. In the present study, the airway responsiveness to aerosolized and injected histamine in congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs was investigated. In addition, the role of the vagal reflex in histamine-induced airway contraction was evaluated by vagal blocking with atropine inhalation or bilateral vagotomy. A significantly higher bronchoconstrictive reaction, i.e., a decrease in tidal volume (VT) and an increase in respiratory resistance (Rrs), to histamine-inhalation was observed in BHS than in BHR. A noticeably lower reduction in VT was noted after atropine pretreatment for both BHS and BHR, whereas an increase in Rrs was inhibited only in BHS. The intravenous injection of histamine caused a noticeable bronchoconstrictive reaction in both BHS and BHR with a dose-dependent relationship, but no significant differences were observed and the bilateral vagotomy failed to induce any difference between the two animal groups. These results demonstrated that the airway responsiveness to histamine is considerably different in BHS from that in BHR, but the difference is largely dependent on the route of administration of histamine. The important role of the vagal reflex on the elicitation of airway contraction was elucidated in both animal groups, and it appeared that the BHS possessed relatively higher dependency on the vagal reflex mechanism than the BHR.

著者

• KUWAHARA Masayoshi

  Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U

• TSUBONE Hirokazu

  Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U

• Sugano Sumio

  Helix Research Institute

• SUGANO Shigeru

  Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Med

• MAEDA Masashi

  Department of Immunology, Pharmacology Research Labs, Astellas Pharma, Inc.

• Kuwahara Masayoshi

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive

• NISHIBATA Ryoji

  Institute of Bio-Active Science, Nippon Zoki Pharmaceutical

• MIKAMI Hiroki

  Institute of Bio-Active Science, Nippon Zoki Pharmaceutical

• BIRUMACHI Jun-ichi

  Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The Un

• KUWAHARA Masayoshi

  Tokyo University

• TSUBONE Hirokazu

  Tokyo University

• Tsubone Hirokazu

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive

• Mikami H

  Institute Of Bio-active Science Nippon Zoki Pharmaceutical

• Maeda Masashi

  Department Of Comparative Pathophysiology Graduate School Of Agriculture And Life Sciences The Unive

• Sugano Shigeru

  Department Of Geriatric And Environmental Dermatology Nagoya City University Graduate School Of Medi

• Nishibata Ryoji

  Institute Of Bio-active Science Nippon Zoki Pharmaceutical

• Mikami Hiroki

  Institute Of Bio-active Science Nippon Zoki Pharmaceutical

• Sugano S

  Department Of Comparative Pathophysiology Graduate School Of Agriculture And Life Sciences The Unive

• Birumachi Jun-ichi

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The Univ

• Kuwahara Masayoshi

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The Univ

• Tsubone Hirokazu

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• SUGANO Shigeru

  Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo

• TSUBONE Hirokazu

  Department Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

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