Augmented Activity of the Pelvic Nerve Afferent Mediated by TRP Channels in Dextran Sulfate Sodium (DSS)-Induced Colitis of Rats
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概要
- 論文の詳細を見る
Enteritis has been recognized as a major symptom in domestic animals and human patients suffering from feed and food poisonings. The aim of the present study was to clarify the excitatory mechanism of the pelvic nerve afferent which may influence the occurrence of enteritis in response to nociceptive chemical stimuli of the colon in normal and abnormal rats with colitis induced by dextran sulfate sodium (DSS). The pelvic nerve afferent activity was markedly increased by colonic instillation of solution (0.5 ml) of acetic acid (5–25%) and capsaicin (100μg/ml). The nerve activity was augmented by colonic instillation of capsaicin to a greater extent in rats with DSS-induced colitis than in normal control rats. This augmented activity by capsaicin was more prominent at one day (DSS-1) than at 8 day (DSS-8) after the administration of DSS. The increased nerve activity caused by capsaicin in DSS-1 and DSS-8 was significantly inhibited by pretreatment with ruthenium red, which is a nonselective inhibitor of TRP channels of unmyelinated C-fibers (nociceptors). In conclusion, it was elucidated that the nociceptive function of the pelvic nerve was largely elevated at one day after DSS-induced colitis and such increased function was mostly mediated by TRP channels.
- 日本獣医学会の論文
著者
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
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Tsubone Hirokazu
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology The University Of Tokyo
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Ito Koichi
Department Of Biomedical Sciences Hirosaki University Graduate School Of Health Sciences
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MAKIMURA Yukitoshi
Department of Comparative Pathophysiology, Division of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
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TSUBONE Hirokazu
Department of Comparative Pathophysiology, Division of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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MAKIMURA Yukitoshi
Department of Comparative Pathophysiology, Division of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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TSUBONE Hirokazu
Department Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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