Effects of sodium bicarbonate on butyric acid-induced epithelial cell damage in vitro
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概要
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Butyric acid is detected in periodontal pockets and is thought to be involved in the initiation and progression of periodontal disease. We examined the effects of sodium bicarbonate on the butyric acid-induced epithelial cell damage. The human gingival carcinoma cell line Ca9-22 was cultured in medium that contained butyric acid with or without sodium bicarbonate. The viability of cells treated with sodium bicarbonate was significantly higher than that of cells treated with butyric acid alone. The effects of butyric acid on ICAM-1 expression were significantly improved by sodium bicarbonate. Within the limitations of this in vitro study, sodium bicarbonate was indicated to be a useful therapeutic agent to reduce the butyric acid-induced periodontal tissue damage. (J. Oral Sci. 50, 413-417, 2008)
著者
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Ito Koichi
Department of Periodontology, Nihon University School of Dentistry
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Arai Noriyuki
Department Of Orthopaedic Surgery Teikyo University School Of Medicine
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Sugano Naoyuki
Department Of Periodontology Nihon University School Of Dentistry
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Ito Koichi
Department Of Biomedical Sciences Hirosaki University Graduate School Of Health Sciences
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OCHIAI Kuniyasu
Department of Bacteriology, Nihon University, School of Dentistry
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Takigawa Satoko
Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
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Ota Noriko
Department of Periodontology, Nihon University School of Dentistry
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Arai Noriyuki
Department of Periodontology, Nihon University School of Dentistry
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