The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive(BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs
スポンサーリンク
概要
- 論文の詳細を見る
Cough elicitation and major physiological factors influencing cough occurrence were investigated in congenitally bronchial-hypersensitive (BHS) and -hyposensitive (BHR) guinea pigs exposed to citric acid (0.3 M) aerosol for 10 min. The number of cough in BHS was significantly larger than in BHR, while the latency to cough in BHS was significantly shorter than in BHR. Pretreatment with atropine (0.2%), lidocaine (2%) or salbutamol (0.1%) aerosol and desensitization of C-fibers with capsaicin (100 mg/kg) decreased the cough numbers in both BHS and BHR. The salbutamol, atropine and capsaicin pretreatments prolonged the cough latency in BHS, but only salbutamol prolonged the latency in BHR. After salbutamol pretreatment all BHR guinea pigs exhibited cough, while 66.7% of BHS guinea pigs exhibited it. Vagal blocking by atropine suppressed coughing in both BHS and BHR. Only a small number (33.3%) of BHR guinea pigs and no BHR guinea pigs exhibited a cough response after capsaicin and lidocaine pretreatment whereas many BHS guinea pigs still produced cough after such pretreatment. The present study demonstrated that the cough responsiveness to citric acid aerosol was significantly higher in BHS than in BHR. It was revealed that airway smooth muscle contraction and functional and/or morphological development of airway nervous receptors, especially C-fiber endings, contributed to aggravation of coughing in BHS.
- 2001-10-01
著者
-
KUWAHARA Masayoshi
Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U
-
TSUBONE Hirokazu
Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U
-
Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
-
NISHIBATA Ryoji
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
-
MIKAMI Hiroki
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical
-
YAGI Yukihiro
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The Un
-
NANJI Atsumi
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The Un
-
BIRUMACHI Jun-ichi
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The Un
-
KUWAHARA Masayoshi
Tokyo University
-
TSUBONE Hirokazu
Tokyo University
-
Tsubone Hirokazu
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
-
Mikami H
Institute Of Bio-active Science Nippon Zoki Pharmaceutical
-
Kuwahara M
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
-
Nanji Atsumi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The Univ
-
Nishibata Ryoji
Institute Of Bio-active Science Nippon Zoki Pharmaceutical
-
Mikami Hiroki
Institute Of Bio-active Science Nippon Zoki Pharmaceutical
-
Yagi Yukihiro
Toxicology And Pharmacokinetics Research Labs. Pharmaceutical Research Center Meiji Seika Kaisha Ltd
-
Birumachi Jun-ichi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The Univ
-
Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The Univ
-
Tsubone Hirokazu
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Sciences The University Of Tokyo
-
TSUBONE Hirokazu
Department Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
関連論文
- Diurnal Fluctuations of Heart Rate, Body Temperature and Locomotor Activity in the House Musk Shrew (Suncus murinus)
- Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats
- Prulifloxacin (PUFX) の肝臓への取り込み機構の解明
- Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits
- Availability of miniature pigs for the evaluation of cardiovascular system affected by drugs(Circulatory system, Proceedings of the 32nd Annual Meeting)
- The Difference in Citric Acid-Induced Cough in Congenitally Bronchial-Hypersensitive(BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs
- Airway Responsiveness to Acetylcholine in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs in Vivo and in Vitro
- Histamine-Induced Airway Contraction in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs
- Involvement of Multiple Transport Systems in the Disposition of an Active Metabolite of a Prodrug-type New Quinolone Antibiotic, Prulifloxacin
- c-Fos suppresses systemic inflammatory response to endotoxin
- Antihypertensive Effects of Peptides in Autolysate of Bonito Bowels on Spontaneously Hypertensive Rats
- The Daily Pattern of Cardiovascular Parameters in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) Rabbits
- Diurnal Variation of Heart Rate, Locomotor Activity, and Body Temperature in Interleukin-1α/β Doubly Deficient Mice
- Power Spectral Analysis of Heart Rate Variability for Assessment of Diurnal Variation of Autonomic Nervous Activity in Guinea Pigs
- The Daily Pattern of Heart Rate, Body Temperature, and Locomotor Activity in Guinea Pigs
- The Daily Pattern of Heart Rate, Body Temperature, Locomotor Activity, and Autonomic Nervous Activity in Congenitally Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs
- Influence of Training on Heart Rate Variability in Young Thoroughbred Horses
- Effect of Acetylcholinesterase Activity on Pathogenesis of Airway Hyperresponsiveness in Guinea Pigs
- Effect of M_2 and M_3 Muscarinic Receptors on Airway Responsiveness to Carbachol in Bronchial-Hypersensitive (BHS) and Bronchial-Hyposensitive (BHR) Guinea Pigs
- 日本最高齢馬シンザンの心電図
- Effects of Insulin-Sensitizing Agent on Autonomic Nervous Function in Zucker-Fatty Rats(Nervous system, Proceedings of the 32nd Annual Meeting)
- Characteristics of Autonomic Nervous Function in Zucker-Fatty Rats : Investigation by Power Spectral Analysis of Heart Rate Variability
- Effects of Pair Housing on Diurnal Rhythms of Heart Rate and Heart Rate Variability in Miniature Swine
- Changes in Autonomic Control of Heart Associated with Classical Appetitive Conditioning in Rats
- Effects of Psychological Stress on Autonomic Control of Heart in Rats
- Charastalistics of delayed rectiire K^+ current in in vivo model of rabbi heart(Proceedings of the 32nd Annual Meeting)
- Morphological Variations in Trnasplanted Tumors Developed by Inoculation of Spontaneous Mesothelioma Cell Lines Derived from F344 Rats
- Evaluation of Band-Gap Energies and Characterization of Nonradiative Recombination Centers of Film and Bulk GaN Crystals
- The Influence of Chronic Sympathectomy on Cutaneous Blood Flow in the Rat Tail
- Heart Rates and Blood Lactate Response in Thoroughbred Horses during a Race
- Temperature Dependence of the Thermal Conductivity and Phonon Scattering Time of a Bulk GaN Crystal
- Arrhythmias and alterations in autonomic nervous function induced by deoxynivalenol (DON) in unrestrained rats
- Arrhythmias and alterations in autonomic nervous function induced by deoxynivalenol (DON) in unrestrained rats
- Enhanced gastric retention of solid resin beads as a marker for emetic potential of agents in rats
- Augmented Activity of the Pelvic Nerve Afferent Mediated by TRP Channels in Dextran Sulfate Sodium (DSS)-Induced Colitis of Rats
- The Posterior Nasal Nerve Plays an Important Role on Cardiopulmonary Reflexes to Nasal Application of Capsaicin, Distilled Water and l-Menthol in Anesthetized Dogs.
- The Effect of Subacute Supplementation of Taurine on Spatial Learning and Memory
- Respiratory and Cardiovascular Reflexes Elicited by Nasal Instillation of Capsaicin to Anesthetized, Spontaneously Breathing Dogs.
- Effects of Perineural Capsaicin Treatment on Compound Action Potentials of Superior Laryngeal Nerve Afferents in Sevoflurane-Anesthetized Dogs.
- Nasal Sensory Receptors Responding to Capsaicin, Water and Tactile Stimuli in Sevoflurane-Anesthetized Dogs.
- Toxic effects of T-2 toxin and deoxynivalenol on the mitochondrial electron transport system of cardiomyocytes in rats