Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC
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概要
- 論文の詳細を見る
The effect of lactose carrier surface property on the inhalation profile of dry powder inhaler (DPI) was evaluated using a micronized drug (Compound A) by inverse gas chromatography (IGC). Mechanofusion with magnesium stearate (Mg-St) or sucrose stearate increased the fine particle fraction (FPF), considered to be due to decrease in the interaction between Compound A and the lactose carrier. The effect of Compound A concentration on FPF was smaller in mechanofusion-processed lactose compared to intact lactose, especially when processed with Mg-St. The relationship between the IGC parameters of the lactose and FPF was also investigated. FPF increased as both the dispersive component of the surface energy and acidity similarity between the lactose carriers and Compound A increased. Although further investigation is necessary, it could be suggested that acidity similarity decreases the interaction between Compound A and lactose, thus contributing to the increase in the FPF. In conclusion, (1) mechanofusion with Mg-St or sucrose stearate could be an effective method to improve FPF of a DPI drug formulation; (2) IGC would be a valuable method to investigate the interaction between a drug and the DPI carrier; and (3) a relationship between surface acidity and inhalation profile was suggested.
- 公益社団法人日本薬学会の論文
- 2006-11-01
著者
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Yonemochi Etsuo
Faculty Of Pharmaceutical Sciences Toho University
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Yonemochi Etsuo
School Of Pharmaceutical Sciences Toho Univ.
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TERADA Katsuhide
Faculty of Pharmaceutical Sciences, Toho University
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Terada Katsuhide
Faculty Of Pharmaceutical Sciences Chiba University
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Terada Katsuhide
Faculty Of Pharmaceutical Sciences Toho University
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Terada Katsuhide
School Of Pharmaceutical Sciences Toho Univ.
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SUZUKI Masahiko
Pharmaceutical Development Laboratories, SANKYO CO., LTD.
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KUSAI Akira
Pharmaceutical Development Laboratories, SANKYO CO., LTD.
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Kusai Akira
Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd.
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KUMON Michiko
Formulation Technology Research Laboratories, Daiichi Sankyo Co., Ltd.
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KUMON Michiko
Pharmaceutical Development Laboratories, Sankyo Co., Ltd.
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Kumon Michiko
Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd.
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Suzuki Masahiko
Formulation Technology Research Laboratories Daiichi Sankyo Co. Ltd.
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