Molecular Behavior and Dissolution Characteristics of Uracil in Ground Mixtures
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概要
- 論文の詳細を見る
Ground mixtures containing uracill were prepared using various additives such as celluloses, proteins, cyclodextrins, enteric coating agents and inorganic compounds in a planetary ball mill. The amorphous state of uracil was observed in the X-ray diffraction patterns of some of the ground mixtures. The results of infrared spectral analysis indicated deprotonation of uracil after 30 h of (30-h) grinding with sodium polyglutamate. All ground mixtures showed the transient supersaturation of uracil in dissolution studies. The initial amount of uracil dissolved from the 30-h ground mixtures with sodium benzoate derivatives, ethylcellulose, hydroxypropylmethylcellulose acetate succinate and proteins was 2.5 to 9-times that dissolved from intact uracil. The crystallinity and solubility of uracil in the ground mixtures were affected by the mixing ratio, grinding time and moisture content of the additive.
- 社団法人日本薬学会の論文
- 1990-09-25
著者
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仲井 由宣
Faculty Of Pharmaceutical Science Chiba University
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武市 陽一郎
Pharmaceutical Research Laboratory
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馬場 一彦
Pharmaceutical Research Laboratory
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馬場 一彦
Pharmaceutical Research Laboratory Taiho Pharmaceutical Co. Ltd.
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武市 陽一郎
大鵬薬品工業
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