Effects of Zaldaride Maleate, an Antidiarrheal Compound, on Intracellular Ca^<2+>-Mediated Short-Circuit Current Response in the Rat Colonic Mucosa
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概要
- 論文の詳細を見る
The effect of zaldaride maleate(ZAL)on intracellular Ca2+−mediated short−curcuit current(Isc)response in rat colonic mucosa was investigated.The Isc response to acetylcholine was partially reduced by the neuronal blocker tetrodotoxin.The tetrodotoxin−sensitive Isc response to acetylcholine was inhibited by ZAL.The tetrodotoxin−insensitive effect, which indicates direct stimulation of acetylcholine in colonic mucosa, was not affected by ZAL.The Isc response to the Ca2+ ionophore A23187 was reduced by ZAL in the presence of tetrodotoxin.These results suggest that ZAL reduces colonic ion secretion by inhibiting a tetrodotoxin−sensitive neuronal pathway and an intracellular Ca2+ pathway in epithelium.
- 社団法人 日本薬理学会の論文
- 2000-05-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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AIKAWA Nobuo
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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KARASAWA Akira
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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OHMORI Kenji
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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Aikawa N
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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