Synergistic Effect of Naphtoquinones on the Mutagenicity of Nitroarene
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概要
- 論文の詳細を見る
Nitro reduction is a critical step in the mutagenic activation of nitroarene. Nitroarene and quinone are known to be reduced by common enzymes, and thus, naphthoquinone (NQ) was studied for its effects on the mutagenicity of nitroarene in the Ames test using Salmonella typhimurium TA98 without S9. The mutagenicity of 1,3-dinitropyrene in TA98 was found to increase 9- and 6-fold as much in the presence of 70 nmol/plate of 2-methyl-1,4-NQ and 2-hydroxy-1,4-NQ, respectively. Mutagenicity also became greater in 1,3,5-trinitronaphthalene, 1-nitropyrene and 3-nitrofluoranthene. Seventy nmol/plate of 2-methyl-1,4-NQ incerased the mutagenicity of 1-nitropyrene by 10.5-fold as much.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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岸 正孝
Biochemical Research Institute Nippon Menard Cosmetic Co. Ltd.
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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OHMORI Kiyomi
Kanagawa Prefectural Institute of Public Health
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KISHI Michiko
Kanagawa Prefectural Health Laboratory
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NAKAOKA Tadayoshi
Kanagawa Prefectural Health Laboratory
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MIYATA Naoki
National Institute of Health Sciences
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Kishi M
Kanagawa Prefectural Health Laboratory
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Ohmori Kiyomi
Kanagawa Prefectural Health Laboratory
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