Promoter and Mutagenic Activity of Particulate Matter Collected from Urban Air

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概要

• 論文の詳細を見る

• Urban air particulate samples were collected on a quartz fiber filter with a High Volume Air Sampler, which was placed on the roof of the National Institute of Public Health, Minato-ku, Tokyo. Those samples were tested in both transformation assay using Bhas42 cells (Bhas assay) as a bioassay for cancer promoters and in the Ames microsuspension method as for initiators. Good dose-response relations were observed with both testing methods, and the samples showed mutagenicity and promoter activity. A comparison per particle weight between the samples collected in spring and autumn indicated that the value was higher in autumn samples, suggesting that mutagenic substances and cancer promoters might be polluting the air and be correlated with each other. Therefore, to monitor the carcinogenic-related activity of air pollutants, not only the mutagenicity assay but also bioassays for cancer promoters are required.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• GOTO Sumio

  Azabu University

• UMEDA Makoto

  Hatano Research Institute, Food and Drug Safety Center

• OHMORI Kiyomi

  Kanagawa Prefectural Institute of Public Health

• FUSHIWAKI Yuichi

  Kanagawa Prefectural Institute of Public Health

• Goto S

  College Of Environmental Health Azabu University

• Goto S

  Reseacrh Center For Material Cycles And Waste Management National Institute For Environmental Studie

• Goto Sumio

  Research Center For Material Cycles And Waste Management National Institute For Environmental Studie

• Mori Yasuaki

  Kanagawa Prefectural Public Health Laboratory

• Mori Y

  Osaka Univ. Osaka Jpn

• Umeda Makoto

  Hatano Research Institute Food And Drug Safety Center

• EZOE Yuka

  Research Center for Material Cycles and Waste Management, National Institute for Environmental Studi

• Ohkubo Tadamichi

  National Institute of Public Health

• Ohmori Kiyomi

  Kanagawa Prefectural Health Laboratory

• Ezoe Y

  Research Center For Material Cycles And Waste Management National Institute For Environmental Studie

• Ezoe Yuka

  Research Center For Material Cycles And Waste Management National Institute For Environmental Studie

• Ohkubo T

  National Institute Of Public Health

• Fushiwaki Y

  Kanagawa Prefectural Institute Of Public Health

関連論文

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• An Interlaboratory Collaborative Study on a Cell Transformation Assay Using Bhas 42 Cells
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• Mutagenicity of Surface Soil in Sagamihara City
• A High-Throughput Cell Transformation Assay Applicable to Automation for Detecting Potential Chemical Carcinogens Using Bhas 42 Cells

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