Genotoxicity of Microbial Volatile Organic Compounds
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概要
- 論文の詳細を見る
Luminescent and light absorption umu tests were used to investigate the genotoxicity of microbial volatile organic compounds (MVOCs), which have been reported to occur in conjunction with the growth of filamentous fungi. Investigation of 20 types of MVOC samples confirmed the SOS-inducing activity of 1-octen-3-ol, 2-methyl-1-propanol, 2-heptanone, 3-octanol, 1-pentanol, 1-butanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 3-methyl-2-butanol, 3-octanone, 2-hexanone, 2-butanone, 3-methyl-2-butanone, 2-pentanol, ethyl isobutyrate, and terpinen-4-ol. Of these materials, 3-methyl-2-butanone and 3-methyl-2-butanol, which were positive in both the luminescent and light absorption umu tests, were clearly shown also to be mutagenic based on the results of the Ames test. Each of these 20 MVOCs is known to be produced by microorganisms commonly detected in indoor environments, and long-term exposure could be a health hazard.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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Takatori Kosuke
Division of Micro biology and Immunochemistry, National Institute of Health Sciences
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NAKAJIMA Daisuke
National Institute for Environmental Studies
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GOTO Sumio
Azabu University
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NAKAJIMA Daisuke
Research Center for Environmental Risk, National Institute for Environmental Studies
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Nakajima Daisuke
Research Center For Environmental Risk National Institute For Environmental Studies
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Goto S
College Of Environmental Health Azabu University
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Goto S
Reseacrh Center For Material Cycles And Waste Management National Institute For Environmental Studie
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Goto Sumio
Research Center For Material Cycles And Waste Management National Institute For Environmental Studie
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Kageyama Shiho
Research Center for Environmental Risk, National Institute for Environmental Studies
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Kageyama Shiho
Research Center For Environmental Risk National Institute For Environmental Studies
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Takatori Kosuke
Division Of Microbiology National Institute Of Health Sciences
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MOROOKA Nobuhisa
Faculty of Pharmaceutical Science, Science University of Tokyo
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Ishii Ruri
Research Center for Material Cycles and Waste Management, National Institute for Environmental Studi
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Onji Yoshiki
Air Environment Division, Nara Prefectural Institute for Hygiene and Environment
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Mineki Shigeru
Faculty of Science and Technology, Tokyo University of Science
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Onji Yoshiki
Air Environment Division Nara Prefectural Institute For Hygiene And Environment
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Ishii Ruri
Research Center For Material Cycles And Waste Management National Institute For Environmental Studie
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Morooka Nobuhisa
Faculty Of Home Economics Koriyama Women 's University
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Nakajima Daisuke
Research Center for Enviromental Risk National Institute for Environmental Studies
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