The Chemical Structure and the Mutagenicity of Emodin Metabolites(Biological Chemistry)

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概要

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• Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occurring anthraquinone formed in rhubarb and fungal metabolites. Emodin was transformed into 6 major metabolites by rat hepatic microsomes. The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by comparison with the synthetic compounds using thin-layer chromatography. It was clear that 2-hydroxyemodin is a proximate mutagen as a synthetic compound by the Salmonella assay. Other metabolites, such as 5-hydroxyemodin and ω-hydroxyemodin, became active after metabolic activation, but 4-hydro-xyemodin and emodic acid were inactive either in the presence or in the absence of the metabolic activation system.

• 社団法人日本農芸化学会の論文
• 1990-05-23

著者

• UENO Yoshio

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• Nakano Sonoko

  Faculty Of Pharmaceutical Science Science University Of Tokyo

• MOROOKA Nobuhisa

  Faculty of Pharmaceutical Science, Science University of Tokyo

• ITOI Noriko

  Faculty of Pharmaceutical Science, Science University of Tokyo

• Ueno Y

  Yashio Inst. Environmental Sci. Tokyo

• Itoi Noriko

  Faculty Of Pharmaceutical Science Science University Of Tokyo

• Morooka Nobuhisa

  Faculty Of Pharmaceutical Science Science University Of Tokyo

• Morooka Nobuhisa

  Faculty Of Home Economics Koriyama Women 's University

• Ueno Yoshio

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Ueno Yoshio

  Faculty Of Pharmaceutical Science Science University Of Tokyo

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