Detection of DNA-Reactive Metabolites in Human Serum after 1, 4-Dichlorobenzene Inhalation : Role of Human Biomonitoring
スポンサーリンク
概要
- 論文の詳細を見る
Three healthy volunteers were exposed to 1, 4-dichlorobenzene (p-DCB) vapor (2.4-2.8ppm) for 1 hr, peripheral blood was taken before and after exposure. Serum was collected and incubated with calf thymus DNA to examine whether there are any DNA-binding metabolites persisting in human serum. Among the 3 subjects we detected 4, 2, and 0 DNA adducts respectively, no differences were found in adduct profiles before or after p-DCB inhalation. The result reflects that qualities and quantities of DNA-reactive metabolites in human sera are different, depending upon individual exposure to environmental carcinogens and their metabolism ability. There were no additional DNA-reactive metabolites found after inhalation exposure to p-DCB.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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Yoshida Toshiaki
Division of Cardiology, Kumamoto City Hospital
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MIYAZAWA HIROSHI
Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology
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GOTO Sumio
Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine
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GOTO Sumio
Azabu University
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MIYAZAWA Hiroshi
NTT Electronics Corporation
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FUKUHARA MORIO
Department of Pharmaceutical Sciences, National Institute of Public Health
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Goto S
College Of Environmental Health Azabu University
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Goto S
Reseacrh Center For Material Cycles And Waste Management National Institute For Environmental Studie
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Goto Sumio
Department Of Orthopaedic Surgery Chiba University Graduate School Of Medicine
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Fukuhara Morio
Department Of Pharmaceutical Sciences
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Yoshida T
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Miyazawa H
Ntt Electronics Corporation
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Yoshida Toshiaki
Division Of Cardiology Kumamoto Central Hospital
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Madhusree Bathini
Department of Pharmaceutical Sciences, National Institute of Pubilc Health
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Tian Hailin
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University
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Tian Hailin
Department Of Physiological Sciences College Of Veterinary Medicine Oklahoma State University
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Fukuhara Morio
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Madhusree B
日本学術振興会
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Madhusree Bathini
Department Of Chemistry S.v.u. Engineering College S.v. University
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Goto Sumio
Department Of Community Environmental Sciences National Instite Of Public Health
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Miyazawa Hiroshi
Department Of Biotechnology Faculty Of Technology Tokyo University Of Agriculture And Technology
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