Relationships between Lifestyle-Related Factors and Immune Parameters in Middle-Aged Male Workers
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概要
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Relationships between Lifestyle-Related Factors and Immune Parameters in Middle-Aged Male Workers:Yumiko NAKANO et al. Division of Industrial Health, Osaka Prefectural Institute of Public Health-Recent studies have demonstrated that unhealthy lifestyles and stress act as risk factors for various cardiocascular diseases, cerebrovascular disorders and cancer. The present study was carried out to investigate the effect of individual lifestyle and comprehensive lifestyle practices on T cell function in peripheral blood lymphocytes in 291 middle-aged male workers belonged to 4 occupational groups:selfemployed men(I), employees of a television station(II), local civil servants(III) and workers in a manufacturing factory(IV). The proliferative responsiveness of the lymphocytes to phytohemagglutinin(PHA) was measured by the incorporaton of radiolabeled thymidine by stimulated lymphocytes in vitro. Interferon-γ(IFN-γ, T helper type 1 cytokine) and interleukin-4(IL-4; T helper type 2 cytokine) production from the stimulated lymphocytes were measured by quantitative sandwich enzyme immunoassay. Interviews by means of questionnaires including 19 items related to lifestyles, work stress, life event and health condition were performed. Subjects were classified into groups reporting healthy and unhealthy lifestyles according to their responses to the individual questionnaire. Then, the relationships between these lifestyle practices and the immune parameters were analyzed at the level of the occupational groups and the pooled subjects. The average number of unhealthy practices differed significantly among occupational groups, i.e., higher in the order of I, II, III and IV. Significantly negative correlations were observed between the number of unhealthy lifestyle practices and the PHA responses both at the level of the occupational groups and the pooled subjects. In contrast, there was no significant difference in IFN-γ production among occupational groups, though the group I showed a somewhat low tendency. The levels of IL-4 in group I were noticeably higher than that in the other groups. It may be possible that severe suppression of cell-mediated immunity changes the balance of T cell subsets from T helper type 1 to T helper type 2. For each lifestyle practice, subjects reporting "healthy" practices on 7 items showed significantly greater proliferative response to PHA than those reporting unhealthy practices. Subjects reporting "healthy" practices on two items showed significantly lower levels of IL-4 compared with those reporting unhealthy practices. A 1.5-yr follow up study performed in the subjects with low PHA responses showed that the reduction of unhealthy lifestyle practices significantly improved the PHA responses. Consequently, the present study suggests that the individual unhealthy lifestyle practices may act on the immune system cumulatively, and the measurement of PHA response may be used to evaluate the lifestyle practices of middle-aged male workers at both the individual and the occupational group level.
- 社団法人日本産業衛生学会の論文
著者
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中村 清一
大阪府立公衆衛生研究所
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中村 清一
大阪大学
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Yoshida Toshiaki
Division of Cardiology, Kumamoto City Hospital
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Naito Yoshihiko
Aomori University Of Health And Welfare Faculty Of Health Science
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Iida M
Department Of Epidemiology And Mass Examination Osaka Medical Center For Cancer And Cardiovascular D
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Sato Shinichi
Chiba Prefectural Institute Of Public Health
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IIDA Minoru
Department of Preventive Cardiology, National Cardiovascular Center
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KIYAMA Masahiko
The Osaka Medical Center for Health Science and Promotion
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KIYAMA Masahiko
Department of Epidemiology and Mass Examination, Osaka Medical Center for Cancer and Cardiovascular
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NAITO Yoshihiko
Department of Epidemiology and Mass Examination, Osaka Medical Center for Cancer and Cardiovascular
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NAKANO Yumiko
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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ANDO Katashi
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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NAKAMURA Seiichi
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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HIRATA Mamoru
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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MATUNAGA Ichiro
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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ODA Hajime
Division of Industrial Health, Osaka Prefectural Institute of Public Health
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SATO Sinichi
Department of Epidemiology and Mass Examination for Cardiovascular Disease, Osaka Medical Center for
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Oda Hajime
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Ando Katashi
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Hirata M
Kyushu Univ. Jpn
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Nakano Y
Univ. Tsukuba Ibaraki Jpn
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Nakano Yumiko
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Matunaga Ichirou
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Hirata Mamoru
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Nakagawa Yuko
Department Of Epidemiology And Mass Examination Osaka Medical Center For Cancer And Cardiovascular D
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Ishimori Mako
Department Of Domestic Science Tokyo Bunka Junior College
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Yoshida Toshiaki
Division Of Cardiology Kumamoto Central Hospital
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Yoshida Toshiaki
Division Of Industrial Health Osaka Prefectural Institute Of Public Health
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Iida Minoru
Department Of Domestic Science Tokyo Bunka Junior College
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Kiyama Masahiko
Osaka Medical Center For Health Science And Promotion
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Kiyama Masahiko
Department of Epidemiology and Mass Examina-tion, The Center for Adult Diseases
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Naito Yoshihiko
Department of Epidemiology and Mass Examina-tion, The Center for Adult Diseases
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