Plasma Fibrinogen, Tissue Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Their Related Factors in Three Japanese Population Samples
スポンサーリンク
概要
- 論文の詳細を見る
To examine population mean variations in plasma fibrinogen and fibrinolytic variables, and their rela tions with cardiovascular risk characteristics among Japanese middle-aged men, a cross-sectional study was conducted for a total of 245 men aged 50-59 years in three population-based samples : residents in rural communities of northeast and central Japan and urban white-collar workers. Age-adjusted mean value of plasma fibrinogen, tissue plasminogen activator antigen (t-PA antigen), plasminogen activator inhibitor 1 antigen (PAI-1 antigen) did not differ significantly among the populations. Mean value of tissue plasminogen activator activity (t-PA activity) was lower in central rural residents than in northeast rural men. According to multiple linear regression analyses, there were positive associations of t-PA and PAI-1 antigens with serum triglyceride levels, serum insulin and waist-hip ratio within each population and the total samples. A positive association between these fibrinolytic variables and usual ethanol intake was also observed. Smoking was significantly associated with plasma fibrinogen and PAI-1 antigen but not with t-PA antigen or activity. Activity of t-PA was inversely associated with body mass index, and a mean difference in t-PA activity was in part explained by a mean difference in body mass index. In conclusion, population mean values of plasma fibrinogen and fibrinolytic variables did not differ among three Japanese populations except for mean t-PA activity. Reduced fibrinolysis expressed as increased PAI-1 antigen was associated with smoking and the status of insulin resistance, such as high levels of serum insulin, serum triglycerides and waist-hip ratio.
- 日本衛生学会の論文
著者
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KUDO MASANOBU
Department of Pediatrics, Hirosaki University School of Medicine
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Ito Hiroyasu
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Iso Hiroyasu
愛媛大学 医学系研究科公衆衛生学
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Naito Yoshihiko
Aomori University Of Health And Welfare Faculty Of Health Science
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Iida M
Department Of Epidemiology And Mass Examination Osaka Medical Center For Cancer And Cardiovascular D
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Sato Shinichi
Chiba Prefectural Institute Of Public Health
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SATO SHINICHI
Departments of Internal Medicine, Sakura National Hospital
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Shimamoto Takashi
The Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
大阪大学 医学系研究科社会環境医学講座公衆衛生学
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Shimamoto T
Shibuya Kogyo Co. Ltd. Kanazawa‐shi Jpn
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Shimamoto T
Faculty Of Engineering The Univ. Of Tokushima
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IIDA Minoru
Department of Preventive Cardiology, National Cardiovascular Center
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UMEMURA Utako
Department of Domestic Science, Tokyo Bunka Junior College
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KOIKE Kazuko
Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences
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ISO Hiroyasu
Institute of Community Medicine, University of Tsukuba
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SHIMAMOTO Takashi
Institute of Community Medicine, University of Tsukuba
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KOMACHI Yoshio
Osaka Prefectural Institute of Public Health
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NAITO Yoshihiko
Department of Epidemiology and Mass Examination, Osaka Medical Center for Cancer and Cardiovascular
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KUDO Minako
Institute of Community Medicine, University of Tsukuba
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UMEMURA Utako
Tokyo Bunka Junior College
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KOMACHI Yoshio
The Osaka Research Institute of Public Health
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Shimamoto Takashi
Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Kudo Masanobu
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences University Of T
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Kudo Minako
Institute Of Community Medicine University Of Tsukuba
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Koike Kazuko
Center For Medical Sciences Ibaraki Prefectural University Of Health Sciences
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Umemura Utako
Department Of Domestic Science Tokyo Bunka Junior College
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Ishimori Mako
Department Of Domestic Science Tokyo Bunka Junior College
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Komachi Yoshio
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Imano Hironori
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Shimamoto Takashi
Institute Of Community Medicine University Of Tsukuba
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Kudo M
Division Of Preventive Medicine Department Of Human Environmental And Social Medicine Faculty Of Med
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Koike Kazuko
Ibaraki Prefectural Univ. Health Sci. Ibaraki Jpn
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Komachi Yoshio
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iida Minoru
Department Of Domestic Science Tokyo Bunka Junior College
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Sato Shinichi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Shimamoto Takashi
Lipid Reference Laboratory Osaka Medical Center For Health Science And Promotion
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Komachi Y
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iso Hiroyasu
Department Of Public Health Medicine Doctoral Program In Social And Environmental Medicine Graduate
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Sato Shinichi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Komachi Yoshio
The Osaka Prefectural Institute of PublicHealth
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Naito Yoshihiko
Department of Epidemiology and Mass Examina-tion, The Center for Adult Diseases
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