High Sodium Intake Strengthens the Association between Angiotensinogen T174M Polymorphism and Blood Pressure Levels among Lean Men and Women: a Community-Based Study
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概要
- 論文の詳細を見る
Evidence on the effect of salt intake on the interaction between angiotensinogen (AGT) T174M polymorphism and high blood pressure is sparse. We therefore conducted a large population-based cross-sectional study of 2,823 men and women aged 30-74 in a Japanese farming community to examine associations between AGT polymorphism and blood pressure levels stratified by age (30-64 and 65-74), body mass index (BMI; median), and salt intake (median) estimated by 24-h urine collection and dietary questionnaire. Our a priori hypothesis is that individuals, particularly younger and non-overweight individuals, with the 174M allele have elevated blood pressure levels in response to higher sodium intake, and thus the association between T174M polymorphism and blood pressure is more evident among individuals with higher sodium intake than those with lower sodium intake. There were no differences in systolic or diastolic blood pressure levels (SBP or DBP) between the TT and TM+MM genotype groups overall. However, the mean difference in DBP between the TM+MM and TT groups was +1.0 mmHg in subjects of younger age (p =0.06), +1.7 mmHg in non-overweight subjects (BMI<23.5 kg/m2, p =0.01), and +2.3 mmHg in younger and non-overweight subjects (p =0.002). Furthermore, among younger and non-overweight subjects, blood pressure differences were larger for those with higher urinary sodium excretion (+3.1 mmHg, p =0.03), those with a higher sodium/potassium excretion ratio (+4.1 mmHg, p =0.007), those with higher present sodium intake score (+3.0 mmHg, p =0.003), and those with higher past sodium intake score (+3.4 mmHg, p <0.001). In conclusion, AGT T174M polymorphism was associated with higher DBP levels in younger and non-overweight Japanese. This association was more evident among subjects with higher sodium intake.
- Japanese Society of Hypertensionの論文
- 2004-01-01
著者
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ISO Hiroyasu
Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduat
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KUDO MASANOBU
Department of Pediatrics, Hirosaki University School of Medicine
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Ito Hiroyasu
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Iso Hiroyasu
愛媛大学 医学系研究科公衆衛生学
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Iso Hiroyasu
筑波大学 人間総合科学研究科社会健康医学
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Shimamoto Takashi
Osaka Medical Center for Health Science and Promotion.
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CUI Renzhe
Department of Public Health Medicine, Graduate School of Comprehensive Human Science and Institute o
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Cui Renzhe
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Shimamoto Takashi
The Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
大阪大学 医学系研究科社会環境医学講座公衆衛生学
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Shimamoto T
Shibuya Kogyo Co. Ltd. Kanazawa‐shi Jpn
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Shimamoto T
Faculty Of Engineering The Univ. Of Tokushima
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TANIGAWA Takeshi
Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba
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YAMAGISHI Kazumasa
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences and Institute
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KUDO Minako
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, University of
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KOMACHI Yoshio
Osaka Prefectural Institute of Public Health
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Graduate School Of Medicine Ehime Un
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Iso Hiroyasu
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences University Of T
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Shimamoto Takashi
Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Yamagishi Kazumasa
Department Of Pubic Health Medicine Graduate School Of Comprehensive Human Sciences University Of Ts
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Kudo Masanobu
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences University Of T
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Komachi Yoshio
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Imano Hironori
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Kudo M
Division Of Preventive Medicine Department Of Human Environmental And Social Medicine Faculty Of Med
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Komachi Yoshio
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iso Hiroyasu
Department Of Internal Medicine Division Of Nephrology And Rheumatology Aichi Medical University Sch
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Shimamoto Takashi
Lipid Reference Laboratory Osaka Medical Center For Health Science And Promotion
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Komachi Y
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iso Hiroyasu
Department Of Public Health Medicine Doctoral Program In Social And Environmental Medicine Graduate
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Ehime University Graduate School Of Medicine
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