Aldosterone Synthase Gene T−344C Polymorphism, Sodium and Blood Pressure in a Free-Living Population: A Community-Based Study
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概要
- 論文の詳細を見る
There have been few epidemiological studies on the gene-environmental interaction between the aldosterone synthase gene (CYP11B2) T−344C polymorphism and sodium in relation to blood pressure in a free-living general population. We hypothesized a priori that persons with the T allele of CYP11B2 would have elevated blood pressure levels in response to a higher sodium intake, and thus the association between the T−344C polymorphism and blood pressure would be more evident among persons with a high sodium intake than among those with a low sodium intake. Study subjects were 2,823 men and women aged 30−74 in a Japanese community. We examined the associations between the T−344C polymorphism and blood pressure levels, stratified by sodium variables estimated by 24-h urinary sodium excretion and a dietary questionnaire. There was no significant difference in blood pressure levels among the CC, TC and TT groups for either or both sexes. However, among persons with higher sodium excretion, mean systolic blood pressure levels tended to be higher in those with the TC (+3.0 mmHg, p=0.06) and TT (+2.9 mmHg, p=0.07) genotypes than in those with the CC genotype, but this tendency was not seen among those with lower sodium excretion (−4.0 mmHg, p=0.03 for TC vs. CC; −3.0 mmHg, p=0.11 for TT vs. CC; p for interaction =0.006). In conclusion, we found no association between CYP11B2 and blood pressure for total subjects or for persons with a higher sodium intake. However, a possible gene−blood pressure association among persons with higher sodium intake needs to be explored further.
- Japanese Society of Hypertensionの論文
- 2007-06-01
著者
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Iso Hiroyasu
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of
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Ito Hiroyasu
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Iso Hiroyasu
愛媛大学 医学系研究科公衆衛生学
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Iso Hiroyasu
筑波大学 人間総合科学研究科社会健康医学
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YAO Masayuki
Department of Pathology Osaka University Graduate School of Medicine
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Shimamoto Takashi
Osaka Medical Center for Health Science and Promotion.
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Iso Hiroyasu
Public Health Department Of Social And Environmental Medicine Division Of Preventive And Environment
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CUI Renzhe
Department of Public Health Medicine, Graduate School of Comprehensive Human Science and Institute o
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Cui Renzhe
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Ikeda Ai
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Shimamoto Takashi
The Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
大阪大学 医学系研究科社会環境医学講座公衆衛生学
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Shimamoto T
Shibuya Kogyo Co. Ltd. Kanazawa‐shi Jpn
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Shimamoto T
Faculty Of Engineering The Univ. Of Tokushima
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TANIGAWA Takeshi
Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba
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YAMAGISHI Kazumasa
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences and Institute
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TABATA Minako
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute
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KOMACHI Yoshio
Osaka Prefectural Institute of Public Health
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Graduate School Of Medicine Ehime Un
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Tabata Minako
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences And Institute O
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Iso Hiroyasu
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences University Of T
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Shimamoto Takashi
Osaka Medical Center For Health Science And Promotion
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Shimamoto Takashi
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Yamagishi Kazumasa
Department Of Pubic Health Medicine Graduate School Of Comprehensive Human Sciences University Of Ts
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Yao Masayuki
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences And Institute O
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Komachi Yoshio
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Imano Hironori
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Komachi Yoshio
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Shimamoto Takashi
Lipid Reference Laboratory Osaka Medical Center For Health Science And Promotion
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Komachi Y
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iso Hiroyasu
Department Of Public Health Medicine Doctoral Program In Social And Environmental Medicine Graduate
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Ehime University Graduate School Of Medicine
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