Metabolic Syndrome and the Risk of Ischemic Heart Disease and Stroke among Middle-Aged Japanese
スポンサーリンク
概要
- 論文の詳細を見る
Limited information is available regarding risk of cardiovascular disease and trends for the metabolic syndrome in Asia. We examined the impact of the metabolic syndrome and its components on risk of cardiovascular disease among middle-aged Japanese according to four criteria. We followed 2,613 subjects from a rural Japanese community who participated in cardiovascular health examinations between 1990 and 1993. After 27,477 person-years of follow-up through 2003, there were 42 incidents of ischemic heart disease, 73 total strokes (54 ischemic and 18 hemorrhagic), and 115 total cases of cardiovascular disease. The metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII), American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF), and Japanese criteria. The multivariable hazard ratios (95%CI) associated with the metabolic syndrome based on NCEP-ATPIII criteria were 2.1 (1.1−4.0) for ischemic heart disease, 1.7 (1.0−2.7) for total stroke, 2.0 (1.2−3.5) for ischemic stroke, 1.1 (0.4−2.8) for hemorrhagic stroke, 2.0 (1.3−3.1) for ischemic cardiovascular disease, and 1.7 (1.2−2.5) for total cardiovascular disease. The population-attributable fractions of the metabolic syndrome based on NCEP-ATPIII criteria were 26−27% for ischemic heart disease and ischemic stroke and 20% for total cardiovascular disease. The metabolic syndrome based on AHA/NHLBI, IDF and Japanese criteria had weaker associations with risk of cardiovascular disease, and the association with risk of ischemic heart disease was not statistically significant. The metabolic syndrome based on NCEP-ATP III criteria predicted risks of ischemic heart disease, ischemic stroke and total cardiovascular disease, whereas that based on three other criteria predicted them less effectively.
- the Japanese Society of Hypertensionの論文
- 2008-10-01
著者
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Iso Hiroyasu
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of
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Ito Hiroyasu
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Iso Hiroyasu
愛媛大学 医学系研究科公衆衛生学
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Iso Hiroyasu
筑波大学 人間総合科学研究科社会健康医学
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Kitamura Akihiko
Osaka Medical Center for Health Science and Promotion.
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Sato Shinichi
Chiba Prefectural Institute Of Public Health
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KIYAMA Masahiko
Osaka Medical Center for Health Science and Promotion, CRMLN Lipid Reference Laboratory
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Iso Hiroyasu
Public Health Department Of Social And Environmental Medicine Division Of Preventive And Environment
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TANIGAWA Takeshi
Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba
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KITAMURA Akihiko
the Osaka Medical Center for Health Science and Promotion
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YAMAGISHI Kazumasa
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences and Institute
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KIYAMA Masahiko
The Osaka Medical Center for Health Science and Promotion
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CHEI Choy-Lye
Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute
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IMANO Hironori
Osaka Medical Center for Health Science and Promotion
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KOMACHI Yoshio
Osaka Prefectural Institute of Public Health
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Graduate School Of Medicine Ehime Un
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Chei Choy-lye
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences And Institute O
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Iso Hiroyasu
Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences University Of T
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Yamagishi Kazumasa
Department Of Pubic Health Medicine Graduate School Of Comprehensive Human Sciences University Of Ts
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Komachi Yoshio
Department Ofepidemiology And Cvd Mass-examination The Center For Adult Diseases Osaka
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Imano Hironori
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Komachi Yoshio
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Kitamura Akihiko
Osaka Medical Center For Health Science And Promotion
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Kiyama Masahiko
Osaka Medical Center For Health Science And Promotion
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Yamagishi Kazumasa
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Komachi Y
Departments Of Public Health Medicine Graduate School Of Comprehensive Sciences And Institute Of Com
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Iso Hiroyasu
Department Of Public Health Medicine Doctoral Program In Social And Environmental Medicine Graduate
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Tanigawa Takeshi
Department Of Public Health Doctoral Program In Social Medicine Ehime University Graduate School Of Medicine
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Kiyama Masahiko
Osaka Center for Cancer and Cardiovascular Disease Prevention
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Kitamura Akihiko
Osaka Center for Cancer and Cardiovascular Disease Prevention
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