Associations of Obesity Measures with Subtypes of Ischemic Stroke in the ARIC Study

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概要

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• Background: Associations between obesity and lacunar, nonlacunar thrombotic, and cardioembolic stroke are not firmly established.Methods: Body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) were recorded at baseline between 1987 and 1989 in the Atherosclerosis Risk in Communities (ARIC) Study for 13 549 black and white adults who were aged from 45 to 64 years and had no history of cardiovascular disease or cancer. The incidence of ischemic stroke subtypes was ascertained from surveillance of hospital records over a median follow-up of 16.9 years. Cox proportional hazards regression analyses adjusted for age, sex, race, education, smoking status and cigarette years, usual ethanol intake, and leisure time sports index were used to estimate hazard ratios (HRs).Results: The ARIC sample at baseline was 43.8% men and 27.3% blacks; mean age was 53.9 years. Mean BMI, waist circumference, and WHR were 27.7 kg/m2, 96.8 cm, and 0.92, respectively. The associations of lacunar (n = 138), nonlacunar (n = 338), and cardioembolic (n = 122) ischemic stroke incidence with obesity measures were all generally positive and linear. The HRs for the highest versus lowest quintile of the 3 obesity measures ranged from 1.43–2.21 for lacunar stroke, 1.90–2.16 for nonlacunar stroke, and 2.37–2.91 for cardioembolic stroke.Conclusions: Although different pathophysiological mechanisms may exist, the incidences of lacunar, nonlacunar, and cardioembolic stroke were all significantly positively associated with the degree of obesity, regardless of the measure used.

• 日本疫学会の論文
• 2010-09-01

著者

• YAMAGISHI Kazumasa

  Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences and Institute

• Yamagishi Kazumasa

  Department Of Pubic Health Medicine Graduate School Of Comprehensive Human Sciences University Of Ts

• Stevens June

  Department Of Nutrition Gillings School Of Global Public Health University Of North Carolina

• Yamagishi Kazumasa

  Department Of Public Health Medicine Graduate School Of Comprehensive Human Sciences And Institute O

• Yatsuya Hiroshi

  Division Of Epidemiology And Community Health School Of Public Health University Of Minnesota

• North Kari

  Department Of Epidemiology And Carolina Center For Genome Sciences Gillings School Of Global Public

• BRANCATI Frederick

  Departments of Medicine and Epidemiology, Johns Hopkins University

• FOLSOM Aaron

  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota

• Folsom Aaron

  Division Of Epidemiology And Community Health School Of Public Health University Of Minnesota

• Brancati Frederick

  Departments Of Medicine And Epidemiology Johns Hopkins University

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