Prediagnostic Plasma Antibody Levels to Periodontopathic Bacteria and Risk of Coronary Heart Disease
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概要
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Many epidemiological studies have indicated that periodontitis is an important risk factor for coronary heart disease (CHD). We examined whether plasma antibody levels to 3 major periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia predicted the risk of CHD events. A nested case-control research design (case: n = 191, control: n = 382), by matching gender, age, study area, date of blood collection, and time since last meal at blood collection, was employed in a large cohort of Japanese community residents.Antibody levels of periodontopathic bacteria were associated with risk of CHD after adjusting for BMI, smoking status, alcohol intake, history of hypertension, history of diabetes mellitus, exercise during leisure time, and perceived mental stress. The association was different by age subgroup. For subjects aged 40-55 years, the medium (31.7-184.9 U/mL) or high tertile plasma antibody level (> 184.9 U/mL) of A. actinomycetemcomitans showed higher risk of CHD (medium: OR = 3.72; 95% CI = 1.20-11.56, high: OR = 4.64; 95% CI = 1.52-14.18) than the low tertile level (< 31.7 U/mL). The ORs of CHD incidence became higher with an increase in IgG level of A. actinomycetemcomitans (P for trend = 0.007). For subjects aged 56-69 years, the high tertile level (> 414.1 U/mL) of P. intermedia was associated with higher risk of CHD (OR = 2.65; 95% CI = 1.18-5.94) in a dose-response fashion (P for trend = 0.007). The possible role of periodontopathic bacteria as a risk factor for CHD incidence was suggested by the results of this study by the elevated antibody level to these bacteria with the increased risk of CHD.
著者
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INOUE Manami
Epidemiology & Prevention, Aichi Cancer Center Research Institute
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Ueno Masayuki
Department Of Food Science And Technology Faculty Of Agriculture Kyushu University
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Iso Hiroyasu
Public Health Department Of Social And Environmental Medicine Division Of Preventive And Environment
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Ikeda Ai
Public Health Department Of Social And Environmental Medicine Osaka University Graduate School Of Me
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Tsugane Shoichiro
Epidemiology And Biostatistic Division National Cancer Center Research Institute
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Kawaguchi Yoko
Department Of Anesthesiology Hirosaki University Graduate School Of Medicine
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Izumi Yuichi
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Ikeda Ai
Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University
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Ueno Masayuki
Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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