Metabolic Syndrome and All-Cause and Cardiovascular Disease Mortality : Japan Public Health Center-Based Prospective (JPHC) Study
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概要
- 論文の詳細を見る
Background: Although the metabolic syndrome (MetS) is considered to be caused primarily by visceral fat accumulation, epidemiological evidence is lacking as to whether or not obesity is an essential element in the syndrome. Methods and Results: Between 1990 and 2005, the Japan Public Health Center-based Prospective (JPHC) Study conducted baseline measurements of metabolic risk factors in 12,412 men and 21,639 women, aged 40-69 years, with no history of cardiovascular disease (CVD) or cancer. To clarify the role of obesity, which the definition of MetS in Japan has adopted as an essential criterion, clustering of risk factors in data grouped according to overweight condition was examined. During a 12.3-year follow-up there were 2,040 deaths, including 947 from cancers and 304 from CVD. MetS significantly increased the hazard ratios for all-cause mortality in women and CVD mortality in men. Non-overweight with ≥2 risk factors had a similar impact on all-cause and CVD mortality. Clustering of metabolic factors caused a linear increase in the hazard ratios for mortality. Conclusions: MetS caused moderate increases in all-cause and CVD mortality. However, the MetS definition requiring obesity may not necessarily identify non-overweight individuals who have a high mortality risk and are more prevalent than subjects with MetS. (Circ J 2009; 73: 878 - 884)
- 社団法人 日本循環器学会の論文
- 2009-04-20
著者
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SAITO Isao
Department of Orthodontics, School of Dentistry, Niigata University
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ISO Hiroyasu
Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduat
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INOUE Manami
Epidemiology & Prevention, Aichi Cancer Center Research Institute
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Iso Hiroyasu
大阪大学 医学系研究科社会環境医学講座公衆衛生学
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TSUGANE Shoichiro
Epidemiology and Biostatistics Division, National Cancer Center Research Institute
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Inoue Manami
Epidemiology And Prevention Div. Res. Center For Prevention And Screening National Cancer Center
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Inoue Manami
Epidemiology And Prevention Division Research Center For Prevention And Screening National Cancer Ce
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Sobue T
National Cancer Center Res. Inst.
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Sobue Tomotaka
Cancer Information Service And Surveillance Division Cancer For Cancer Control And Information Servi
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Sobue Tomotaka
Cancer Information And Epidemiology Division National Cancer Center Research Institate
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Kokubo Yoshihiro
Preventive Cardiology National Cardiovascular Center
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Tsugane S
Epidemiology And Prevention Division Research Center For Prevention And Screening National Cancer Ce
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Tsugane Shoichiro
National Cancer Center Research Institute
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Tsugane Shoichiro
Epidemiology And Biostatistic Division National Cancer Center Research Institute
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Tsugane Shoichiro
Epidemiology And Prevention Division Research Center For Prevention And Screening National Cancer Ce
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Iso Hiroyasu
Department Of Internal Medicine Division Of Nephrology And Rheumatology Aichi Medical University Sch
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Tsugane Shoichiro
Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca
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Iso Hiroyasu
Public Health Department Of Social And Environmental Medicine Graduate School Of Medicine Osaka Univ
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Inoue Manami
Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca
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Inoue Manami
Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca
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Saito Isao
Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School
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Saito Isao
Department Of Materials Chemistry And Engineering School Of Engineering Nihon University
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Saito Isao
Department Of Cardiovascular Disease Research Eisai Tsukuba Research Laboratories
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Tsugane Shoichiro
Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca
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