Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma
スポンサーリンク
概要
- 論文の詳細を見る
Background: Localized scleroderma (LSc) is characterized by cutaneous fibrosis and various autoantibodies. Objective: To determine the presence or levels of antibodies (Abs) against matrix metalloproteinase (MMP)-1 and their clinical relevance in LSc. Methods: Anti-MMP-1 Ab was examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) and immunoblotting using human recombinant MMP-1. MMP-1 collagenase activity was determined using biotinylated collagen as substrate and the amount of cleaved biotinylated fragments of collagen by MMP-1 was measured by ELISA. Results: LSc patients exhibited significantly elevated IgG anti-MMP-1 Ab levels relative to normal controls at similar level of patients with systemic sclerosis (SSc). However, IgG anti-MMP-1 Ab levels were comparable among the 3 LSc subgroups: morphea, linear scleroderma, and generalized morphea. When absorbance values higher than the mean + 2S.D. of normal controls were considered positive, IgG or IgM anti-MMP-1 Ab was found in 46% and 49% of total LSc patients and SSc patients, respectively. Anti-MMP-1 Ab was detected most frequently in morphea patients (60%), followed by linear scleroderma patients (47%) and then generalized morphea patients (25%). LSc patients positive for IgG anti-MMP-1 Ab had elevated levels of IgG anti-single-stranded DNA Ab, IgG anti-nucleosome Ab, and shorter disease duration relative to those negative. The presence of anti-MMP-1 Ab in LSc patients was confirmed by immunoblotting. IgG isolated from LSc patients' sera positive for IgG anti-MMP-1 Ab by ELISA inhibited MMP-1 collagenase activity. Conclusion: These results suggest that anti-MMP-1 autoantibody is a novel autoantibody in LSc. © 2008 Japanese Society for Investigative Dermatology.
- 2008-10-01
著者
-
HASEGAWA Minoru
Department of Dermatology, Kanazawa University Hospital
-
FUJIMOTO Manabu
Department of Dermatology, Kanazawa University Hospital
-
Fujimoto Manabu
鹿児島大学病院 呼吸器ストレスケアセンター
-
Fujimoto Manabu
Department Of Dermatology Kanazawa University Graduate School Of Medical Science
-
Fujimoto Manabu
Department Of Cardiology Kanazawa National Hospital
-
Shimizu Kazuhiro
Departments Of Cardiovascular Center Sakura Medical Center School Of Medicine Toho University
-
Iwata Yohei
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Komura Kazuhiro
Department Of Dermatology Kanazawa University Graduate School Of Medical Science
-
Hasegawa Minoru
Department Of Dermatology Kanazawa University Graduate School Of Medical Science
-
SATO SHINICHI
Departments of Internal Medicine, Sakura National Hospital
-
Ogawa Fumihide
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Hara Toshihide
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Takenaka Motoi
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Muroi Eiji
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
TOMIMURA Saori
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
-
Shimizu K
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Shimizu Kazuhiro
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Tomimura Saori
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Hasegawa Minoru
Department Of Dermatology Kanazawa University School Of Medicine
-
Sato Shinichi
Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences
-
Sato Shinichi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
-
Hasegawa Minoru
Department Of Dermatology Kanazawa University Hospital
-
Sato Shinichi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
-
Shimizu Kazuhiro
Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center
関連論文
- Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis
- Myocardial Damages in Systemic Sclerosis Detected by Gated Myocardial Perfusion SPECTand Sympathetic Imaging
- Acutely Exaggerated Hepatitis B Induced by the Withdrawal of Immunosuppressants in a Seroconverted Renal Transplant Recipient : Report of a Case
- Hot-Wall Chemical-Vapor-Deposition of Amorphous-Silicon and Its Application to Thin-Film Transistors
- Autoantibodies against matrix metalloproteinase-1 in patients with localized scleroderma
- PE-218 The Patients with Severe Heart Failure Present Respiratory Oscillation and the Abnormal Power Increase in Fractal Analysis during the Daytime(PE037,Obesity/SAS 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circul
- PJ-852 Central Type Sleep Apnea Syndrome Presents Spear-Shaped Abnormal Power Increase in Fractal Analysis of Heart Rate Variability(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- B cell signaling and autoimmune diseases: CD19/CD22 loop as a B cell signaling device to regulate the balance of autoimmunity
- CD19 and CD22 Regulate a B Lymphocyte Signal Transduction Pathway That Contributes to Autoimmunity
- A Case of Recurrent Ampullar Carcinoma Undergoing Photodynamic Therapy after Surgical Resection
- Mouse CD20 expression and function
- Serum BAFF and APRIL levels in patients with alopecia areata
- Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid
- CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells
- Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome
- Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice.
- PJ-240 A Prediction of Presence of Sleep Apnea Syndrome by Fractal Analysis of Heart Rate Variability(ECG/Body surface potential mapping/Holter-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A Case of Bullous Pemphigoid Arising in Juvenile Hyaline Fibromatosis with Oral Squamous Cell Carcinoma
- The Induction of Heme Oxygenase-1 by Exogenous Nitric Oxide in ex vivo Normal Human Skin
- Expression of Superoxide Dismutase in Basal Cell Carcinoma
- Analysis on the resistive forces acting on the bucket of a Load-Haul-Dump machine and a wheel loader in the scooping task
- 0646 EFFECTS OF ENDOSCOPIC TRANSTHORACIC SYMPATHICOTOMY ON CIRCADIAN VARIATION OF CARDIAC AUTONOMIC ACTIVITY
- 0847 Influence on Autonomic Balance During Head-up TiIt of Endoscopic Transthoracic Sympathicotomy
- -0410- EFFECT OF ENDOSCOPIC THORACIC SYMPATHECTOMY ON AUTONOMIC NERVOUS CONTROL OF THE HEART(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Cardiac Sympathetic Nervous System Represses Natriuretic Peptide Release in Humans
- Relationship between plasma homocysteine and coronary stenosis morphology in Japanese patients with coronary artery disease
- Effects of Endoscopic Transthoracic Sympathicotomy on Hemodynamic and Neurohumoral Responses to Exercise in Humans
- A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica
- Validity and Reliability of the Japanese Version of the Selected Anger Expression Scale and Age, Sex, Occupation and Regional Differences in Anger Expression Among Japanese
- Plasma Fibrinogen, Tissue Plasminogen Activator, Plasminogen Activator Inhibitor 1, and Their Related Factors in Three Japanese Population Samples
- Catamenial Hemoptysis
- Normal Pulmonary Geometric Changes Due to Respiration: Evaluation with Inspiratory and Expiratory Spiral CT
- Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis
- Clinical association of serum interleukin-17 levels in systemic sclerosis: Is systemic sclerosis a Th17 disease?
- Marked Effect of Steroid-Resistant Focal Sclerotic Nephrotic Syndrome by Concomitant Therapy with LDL-Apheresis and Cyclosporine
- PE-328 Relationship Between Preheparin Serum Lipoprotein Lipase Mass and Multiple Risk Factors Clustering Syndrome(Atherosclerosis, Clinical 6 (IHD) : PE56)(Poster Session (English))
- OJ-076 Clinical Significance of Urinary 8-iso-prostaglandin F2 α Levels in Patients with Percutaneous Coronary Intervention(Coronary Revascularization, PICA/Stent/DCA/Rotablator/New Device 1 (IHD) : OJ9)(Oral Presentation (Japanese))
- FRS-164 Low Preheparin Serum Lipoprotein Lipase Mass is a Predictive Factor for Stent Restenosis(Coronary Heart Disease : Basic Science (IHD) : FRS20)(Featured Research Session (English))
- Changes in Cardiovascular Risk Factors Related with Menopause in Rural Japanese Women
- Trends for Coronary Heart Disease and its risk Factors in Japan : Epidemiologic and Pathologic Studies : 53th Annual Scientific Session of the Japanese Circulation Society
- Autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach
- Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension
- Clinical association of serum CD137 (4-1BB) levels in patients with systemic sclerosis
- Drug-Induced Hypersensitivity Syndrome Associated with Human Herpesvirus 6 and Cytomegalovirus Reactivation
- Prevalence and clinical characteristics of anti-Mi-2 antibodies in Japanese patients with dermatomyositis
- Pathogenesis of systemic sclerosis : Altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
- Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis
- Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis
- Association between Cardio-Ankle Vascular Index and Serum Cystatin C Levels in Patients with Cardiovascular Risk Factor
- PE-055 Angioscopic Detection of Pulmonary Thromboemboli and Their Classification(PE010,Thromboembolism/Antithrombotic Therapy/Thrombolysis 1 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-533 Inreased CAVI is associated with Renal Dysfunction than Carotid Atherosclerosis Findings(Kidney/Renal circulation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-709 Ultrasonic Elastography Imaging of Deep Venous Thrombosis(Pulmonary circulation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-168 Evaluation of Coronary Flow Velocity Pattern with Transthoracic Doppler Echocardiography Predict Recovery of LV Function after Reperfusion Therapy Using Thrombectomy(Acute myocardial infarction, clinical (diagnosis/treatment)-8, The 71st Annual Sci
- PE-626 New Application of Angioscopy for Evaluation of Deep Venous Thrombosis(Thromboembolism/Antithrombotic therapy/Thrombolysis-3 (H) PE111,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-623 Application of Ultrasonographic Elastography for Evaluation of Deep Venous Thrombosis(Thromboembolism/Antithrombotic therapy/Thrombolysis-3 (H) PE111,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
- Relationship between Serum Adiponectin Levels and Glucose Tolerance, Insulin Secretion in Patients with Coronary Artery Disease(Diabetes/Obesity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between Preheparin Serum Lipoprotein Lipase Mass and Metabolic Syndrome in Patients with Coronary Artery Disease(Atherosclerosis, Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between Urinary 8-Iso-ProstaglandinF2α and Coronary Atherosclerosis(Angina Pectoris, Basic/Clinical 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Low Preheparin Serum Lipoprotein Lipase Mass is an Important Coronary Risk Factor in Female(Angina Pectoris, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis : an Intravascular Ultrasound Study(Atherosclerosis, Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-563 Preventive effects of Evans'blue on restenosis after PCI : 7th report(Restenosis after Angioplasty, Basic/Clinical 6 (IHD) : PJ94)(Poster Session (Japanese))
- Non-invasive and ambulatory monitoring of beat-to-beat cardiovascular hemodynamic variables in patients with hemodiatysis
- Autocrine/Paracrine Involvement of Parathyroid Hormone-Related Peptide in Vascular Leiomyoma
- Five cases of necrotizing fasciitis : Lack of skin inflammatory signs as a clinical clue for the fulminant type
- Drastic Enlargement of Grain Size of Excimer-Laser-Crystallized Polysilicon Films
- Cloning and Expression of the Momordica charantia Trypsin Inhibitor II Gene in Silkworm by using a Baculovirus Vector
- Method of Evaluating the Liquid-Liquid Dispersion by the Indices Defined Based on Shape of the Drop Size Distribution in Various Impeller Stirred Tanks
- Fabrication of Nanostructure by Anisotropic Wet Etching of Silicon : Techniques, Instrumentations and Measurement
- Fabrication of MOS Nanostructure by Employing Electron Beam Lithography and Anisotropic Wet Etching of Silicon
- Redo total aortic arch replacement using an extended homograft for graft infection
- Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies
- Secondary cutaneous candidiasis with eosinophilia
- Extramammary Paget's disease with intracytoplasmic lumen formation
- Change of suicidal ideation induced by suicide attempt
- Simultaneous Control of Regio- and Stereoselectivity in the Reaction of Pentadienyltin by the Lewis Acid-Coordination to Its Ethereal Functionality
- B lymphocytes : Shedding new light on the pathogenesis of systemic sclerosis
- Nanometer Patterning by Electron Beam Lithography Using an Amorphous Carbon Film as an Intermediate Layer
- Case of localized scleroderma associated with osteomyelitis.
- Serum levels of CCL 17/TARC in various skin diseases
- Granular Cell Tumor of the mediastinum : CT and MRI features
- High-Performance Poly-Si Thin-Film Transistors with Excimer-Laser Annealed Silicon-Nitride Gate
- High-Mobility Bottom-Gate Thin-Film Transistors with Laser-Crystallized and Hydrogen-Radical-Annealed Polysilicon Films
- Expression and Promoter Activity of Genes for Isozymes of Horseradish Peroxidase : GENE STRUCTURE AND EXPRESSION
- Clinical and Pathological Findings of Interstitial Lung Disease Patients with Anti-Aminoacyl-tRNA Synthetase Autoantibodies
- IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis and sialoadenitis
- Dermoscopy findings of nail fold capillaries in connective tissue diseases
- Elevated serum placenta growth factor (PlGF) levels in patients with systemic sclerosis : A possible role in the development of skin but not lung fibrosis
- The 1st JSID Kisaragi Juku : The junior tutors' perspective
- CD19 and CD22 Regulate a B Lymphocyte Signal Transduction Pathway That Contributes to Autoimmunity
- Regulatory B cells in skin and connective tissue diseases
- Esophageal transit study using a sliding sum image: application to patients with probable and definite systemic sclerosis
- Increased serum levels of a proliferation-inducing ligand in patients with bullous pemphigoid
- Enhancement of Pressure-Induced Hemolysis by Aquaporin-1 Inhibitors in Human Erythrocytes
- Reinvestigation of Drugs and Chemicals as Aquaporin-1 Inhibitors Using Pressure-Induced Hemolysis in Human Erythrocytes
- A case of biventricular pacing with a spike on T-wave caused by the algorithm maintaining biventricular pacing rate
- The roles of P-and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas
- High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis
- Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions
- Conversion of disilanes to functional monosilanes. IV. Synthesis of methyldichlorosilane and dimethylchlorosilane by the reaction of methylchlorodisilanes with hydrogen chloride in the presence of tetrakis(triphenylphosphine)palladium(0).
- Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease : a report of two cases