Mutagenicity Testing of 1,3-Butadiene, 1,4-Pentadiene-3-ol , Isoprene, 2,4-Hexadiene, cis-and trans-Piperlylene

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A mutagenicity test was conducted for 1,4- pentadiene-3-ol, 2,4-hexadiene, isoprene, cis-and transpiperylene in the bacterial mutation assay using Salmonella typhimurium (S. typhimurium) strain TA 100,TA98,TA1535 and Escherichia coli (E. coli) WP2uvrA/pKM1O1 with and without metabolic activation by S9 mix in the preincubation method. The mutagenicity of 1,3-butadiene was tested by the gas exposure method. Mutagenicity was weakly positive for 1,4-pentadiene-3-ol in TA 100 with S9 mix and was pseudopositive for WP2uvrA/pKM101 without S9 mix. Mutagenicity was very clear for 1,3-butadiene in 10 fold concentrated TA1535 with S9 mix. The 2,4-hexadiene, isoprene, cispiperlylene and trans-piperlylene were not mutagenic on S. typhimurium TA98,TA100,TA1535 or E. coli WP2uvrA/pKM101 with or without metabolic activation. It can be concluded from these results, that chemicals, containing double bond carbon (C=C) chemical generally tend to show weak mutagenicity in the presence of the metabolic activation system.
2002-02-01