The Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Acetylcholine-Induced Intestinal Electrolyte Secretion
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概要
- 論文の詳細を見る
The effect of zaldaride on acetylcholine-induced colonic electrolyte secretion was examined. The short-circuit current response to acetylcholine was partially reduced by tetrodotoxin, a neuronal blocker, and was completely inhibited by atropine, an acetylcholine M receptor antagonist, in the rat colonic preparations. The tetrodotoxin sensitive effect was significantly inhibited by zaldaride, whereas the tetrodotoxin insensitive effect was not affected. Acetylcholine release from synaptosomes of submucosal nerves of guinea-pig colon was significantly reduced by zaldaride. Zaldaride may reduce colonic electrolyte secretion by acetylcholine due to the inhibition of acetylcholine release from synaptosomes of colonic submucosal nerves.
- 社団法人日本薬学会の論文
- 2000-11-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori K
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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KISHIBAYASHI Nobuyuki
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Kogyo Co., Ltd.
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AIKAWA Nobuo
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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KISHIBAYASHI Nobuyuki
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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KARASAWA Akira
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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OHMORI Kenji
The Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co.
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Aikawa N
Kyowa Hakko Kogyo Co. Ltd. Shizuoka Jpn
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Ohmori K
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Kishibayashi N
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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