Rhein, an Active Metabolite of Diacerein, Suppresses the Interleukin-1α-Induced Proteoglycan Degradation in Cultured Rabbit Articular Chondrocytes
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概要
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Diacerein has proved to be effective in the treatment of osteoarthritis. We investigated the effects of rhein, an active metabolite of diacerein, on the degradation of recombinant human interleukin-1α (rhIL-1α)-induced proteoglycan and matrix metalloproteinases (MMPs) release from rabbit articular chondrocytes. Chondrocytes were treated for 24 h with rhein in the presence of rhIL-1α. Rhein suppressed the rhIL-1α-induced proteoglycan degradation. In addition, rhein decreased the rhIL-1α-induced proMMP-3 production and reduced the MMPs activity. These results suggested that diacerein might have a protective effect on proteoglycan degradation via the suppressive effect of rhein on the production of proMMPs.
- 社団法人 日本薬理学会の論文
- 2001-01-01
著者
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OHMORI Kenji
Department of Crystalline Materials Science, Graduate School of Engineering, Nagoya University
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Ohmori Kenji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Ohmori Kenji
Department Of Pharmacology University Of Obihiro School Of Veterinary Medicine
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Tamura Tadafumi
Pharmaceutical Resaerch Institute Kyowa Hakko Kogyo Co. Ltd.
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