PROTECTIVE EFFECT OF FLUNARIZINE AGAINST CEREBRAL HYPOXIA-ANOXIA IN MICE AND RATS
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概要
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The protective effect of flunarizine against cerebral hypoxia-anoxia was investigated with various experimental models in mice and rats. The effect of flunarizine was compared with those of cinnarizine, verapamil and pentobarbital. The oral treatment of animals with flunarizine resulted in a consistent and long-lasting protection against cerebral hypoxia-anoxia in all the models examined : Cytotoxic anoxia by KCN injection, hypercapnic anoxia induced by stopping artificial respiration, hypobaric hypoxia and normobaric hypoxia. The minimal effective dose of flunarizine was 1 to 20 mg/kg. The activity of flunarizine was 4 to 30 times as potent as that of cinnarizine and pentobarbital. Verapamil showed little or no protective effect. The mode of action of flunarizine was different from that of pentobarbital, which showed protection at anaesthetizing doses. These results indicate that flunarizine possesses a universal protective effect against cerebral hypoxia-anoxia, though the mechanism involved remains to be clarified. Hence, it is suggested that flunarizine might exert a beneficial effect on oxygen insufficiency of the brain resulting from cerebral ischemia.
- 公益社団法人日本薬学会の論文
著者
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Karasawa Akira
協和醗酵工業
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Karasawa A
Drug Development Research Laboratories Pharmaceutical Research Institute Kyowa Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Laboratory Of Plant Pathology Department Of Applied Life Science Graduate School Of Agricultural Sci
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YAMADA Koji
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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SHUTO KATSUICHI
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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NAKAMIZO NOBUHIRO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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KUMADA YOKO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Shuto K
Kyowa Hakko Kogyo Co. Ltd. Yamahuchi Jpn
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Shuto Katsuichi
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Yamada Koji
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Karasawa Akira
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Nakamizo Nobuhiro
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Yamada Koji
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KUMADA Yoko
Pharmaceuticals Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Nakamizo Nobuhiro
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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