.GAMMA.-Radiolysis of 1-substituted 5-fluorouracil derivatives.
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概要
- 論文の詳細を見る
A new concept, "Radiation-Induced Drug (RID)", was proposed as a novel type of drugs for cancer therapy. To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied. The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high <I>G</I> values upon γ-irradiation. The medium effects on the radiolyses revealed that the above two substituents were removed mainly with HO· and hydrated electrons e<SUB>eq</SUB><SUP>−</SUP>.
- 公益社団法人 日本化学会の論文
著者
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Nakamizo Nobuhiro
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Kuroda Tokuyuki
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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Hisamura Koji
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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Matsukuma Ikuo
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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Nishikawa Hiroshi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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Nakamizo Nobuhiro
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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- .GAMMA.-Radiolysis of 1-substituted 5-fluorouracil derivatives.