Elecrochemical Stability of Desmopressin Acetate during Iontophoresis
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概要
- 論文の詳細を見る
The electrochemical stability of desmopressin acetate (DDAVP) was investigated. After a direct current of 1 mA was passed through two electrodes chosen from platinum, silver and silver chloride, the decomposition of DDAVP was observed. The degradation products of DDAVP yielded with a Pt(anode) and AgCl(cathode) pair were similar to those observed in an anodic donor after in vivo iontophoresis. Although the Ag(anode)/Pt(cathode) degradation pattern of DDAVP was similar to that of an in vivo cathodic donor HPLC chromatogram, it was different from that of the anodic donor. In the anodic system, the stability of DDAVP was independent of the pH, and decreased with increasing concentration of NaCl.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Kuroda Takeshi
Faculty Of Pharmaceutical Sciences Fukuoka University
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HAYAKAWA Eiji
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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ITO Kunio
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Itoh K
Drug Formulation Research Laboratories Phaemaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ito Kunio
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KATO Yasuki
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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KATO Yasuki
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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Kato Yasuki
協和醗酵工業
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Hayakawa E
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd
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Hayakawa Eiji
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Kuroda T
Faculty Of Pharmaceutical Sciences Fukuoka University
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NAKAMURA Masashi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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KURODA Tokuyuki
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Ito K
Janssen Pharmaceutical K.k. Shizuoka Jpn
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Kato Yasuki
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Nakakura M
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Hayakawa Eiji
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., LTD
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Kuroda Tokuyuki
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co. Ltd.
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