Safe and Efficient Transdermal Delivery of Desmopressin Acetate by Iontophoresis in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Iontophoretic delivery of desmopressin acetate (DDAVP) was assessed for delivery efficiency and drug stability, both in vitro and in vivo. The effect of current intensity and duration of current application on the decomposition of DDAVP was investigated in vitro. It was shown that when a current of 0.1 mA was applied for 5 min, the decomposition of DDAVP was negligible. In vivo experiments under the same conditions showed that the antidiuretic response to DDAVP persisted for about 6 h. Furthermore, when this iontophoresis was repeated 3 times at intervals of 4 h, the antidiuretic response persisted for about 11 h. These results suggest that repeated short-termiontophoresis is a safe and effective technique for transdermal delivery of DDAVP.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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ITO Kunio
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Itoh K
Drug Formulation Research Laboratories Phaemaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Ito Kunio
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KATO Yasuki
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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KATO Yasuki
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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Kato Yasuki
協和醗酵工業
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NAKAKURA Masashi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Ito K
Janssen Pharmaceutical K.k. Shizuoka Jpn
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Kato Yasuki
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Nakakura M
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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