Histological Study of the Accelerating Effect of Shikonin and Alkannin on the Proliferation of Granulation Tissue in Rats
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概要
- 論文の詳細を見る
The present study was carried out to compare the histological changes induced by shikonin and alkannin on the proliferation of granulation tissue in rats. Shikonin and alkannin increased the ratio of CD1 lb^+ cells in the granulation tissue 5 and 10 d after implantation of the cotton pellet, and new blood vessel cells and α-smooth muscle actin were observed around the granulation tissue 5 d after implantation of the cotton pellet. Both compounds increased the expression of CD1 lb^+ cells with granulocytes such as macrophages, histiocytes and TGF-β, and then accelerated the proliferation of fibroblasts and collagen fiber in the gamulation tissue. On the other hand, neither compound increased the ratio of CD3^+ cells in the granulation tissue after 5 and 10 d. These results suggest that the accelerating effect of the proliferation of granulation tissue induced by the cotton pellet produced by shikonin and alkannin can be attributed to an increase in new blood vessel cells and in the expression of CD1 lb^+ cells and TGF-β, and then the acceleration in the proliferation of fibroblasts and collagen fiber in the granulation tissue.
- 日本生薬学会の論文
- 2002-04-20
著者
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尾崎 裕
城西大学薬学部
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ozaki Y
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Ozaki Y
National Inst. Health Sci. Tokyo Jpn
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Ozaki Yukihiro
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Ono Kageyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Sakaguchi Ikuyo
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ono Kageyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Siences
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Sakaguchi Ikuyo
Depatrment of Reserch and Development, Club Cosmetics Co., Ltd.
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Kato Yoshiko
Depatrment of Reserch and Development, Club Cosmetics Co., Ltd.
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Ozaki Yukihiro
Division of Pharmacognosy and Phytochemistry , National Institute of Health Sciences
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