Granulomatous Tissue Formation of Shikon and Shikonin by Air Pouch Method
スポンサーリンク
概要
- 論文の詳細を見る
"The extract of shikon"(SK)and shikonin play important roles in the development of granulamatous tissue formation. To revealthe augmenting effect of SK or shikonin on vascular endothelial growth factor(VEGF)production and neovascularization, we investigated murine granulomatous tissue induced by SK and shikonin, comparing them to pouches in which trehalose 6, 6´-dimysolate(TDM)was injected. The development of granulamatous tissue formation was evaluated by the wet weight of pouch walls. At day 5 and 7 after SK and shikonin injection, prominent granulomatous tissue formation was detected. Histological observations on the development of granulomatous tissue showed that the pouch was formed in the submuscular connective tissue developed in the connective tissue. At day, 1, VEGF-positive neutrophils accumulated in the pouch wall. Granulomatous tissue formation and neovascularization by injection of SK or shikonin was not more prominent than TDM. However, the present results indicate that SK and shikonin induce neovascularization in granulomatous tissue.
- 社団法人日本薬学会の論文
- 2001-06-01
著者
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WATABE Kazuhito
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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KANEDA Kenji
Department of Anatomy, Osaka City University Medical School
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Kaneda Kenji
クラブコスメチックス
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Kaneda K
Osaka City Univ. Medical School
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SAKAGUCHI Ikuyo
Institute of Cosmetic Scineces, Club Cosmetics Co., Ltd.
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TSUJIMURA Masae
Institute of Cosmetic Scineces, Club Cosmetics Co., Ltd.
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IKEDA Norikazu
Institute of Cosmetic Scineces, Club Cosmetics Co., Ltd.
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MINAMINO Miki
Institute of Cosmetic Scineces, Club Cosmetics Co., Ltd.
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KATO Yoshiko
Institute of Cosmetic Scineces, Club Cosmetics Co., Ltd.
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YANO Ikuya
Japan BCG Laboratory
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Minamino Miki
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ikeda Norikazu
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ikeda Norikazu
クラブコスメチックス
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YANO Ikuko
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Tsujimura Masae
Institute Of Cosmetic Scineces Club Cosmetics Co. Ltd.
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Kaneda Kenji
Department Of Bacteriology Niigata University School Of Medicine
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Kimura Koichi
Department Of Microbiology
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Kaneda Kenji
Department Of Anatomy Osaka City University Medical School
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Kato Yoshiko
Institute For Clinical Research Mie National Hospital
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Yano Ikuya
Japan Bcg Central Laboratory
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Yano I
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Watabe Kazuhito
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Sakaguchi Ikuyo
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Kaneda K
Department Of Food Science Shizuoka Eiwa Gakuen University Junior College
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Kaneda Kenji
Department Of Anatomy Osaka City University Graduated School Of Medicine
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