A Novel Immunomodulator, FTY720, Prevents Development of Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice(Pharmacology)
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概要
- 論文の詳細を見る
Prophylactic oral administration of a novel immunomodulator (immunosuppressant), FTY720 (1mg/kg, three times a week), completely prevented the development of experimental autoimmune myasthenia gravis (EAMG) in C57BL/6 mice. EAMG has been used as an animal model for human myasthenia gravis, and was established by immunizing the mice with acetylcholine receptor (AChR) from Torpedo californica. FTY720 also suppressed the production of both anti-Torpedo californica AChR antibody and anti-mouse AChR autoantibody by the mice, which were observed in mice in which EAMG had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human myasthenia gravis.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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吉川 弘明
金沢大学保健管理センター
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KOHNO Takeyuki
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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TSUJI Takumi
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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HIRAYAMA Kaori
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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IWATSUKI Rumi
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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HIROSE Michitaka
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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WATABE Kazuhito
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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YOSHIKAWA Hiroaki
Health Service Center, Kanazawa University
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KOHNO Tomoko
Research Institute for Production Development
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MATSUMOTO Akiko
Research Institute for Production Development
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FUJITA Tetsuro
Research Institute for Production Development
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HAYASHI Masatoshi
Department of Pediatrics, Uwajima City Hospital
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Tsuji Takumi
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Fujita Tetsuro
Res. Inst. For Production Dev.
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Hirayama Kaori
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Kohno Takeyuki
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Watabe Kazuhito
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Iwatsuki Rumi
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Matsumoto Akiko
Research Institute For Production And Development
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Hirose Michitaka
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Hayashi Masatoshi
Department Of Pediatrics Uwajima City Hospital
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Hayashi Masatoshi
Department Of Electrical & Computer Engineering Faculty Of Technology Kanazawa University
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Fujita Tetsuro
Research Institute for Production and Development
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HAYASHI Masatoshi
Department of Agricultural Chemistry, Nagoya University
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